Imaging in CNS Drug Discovery and Development - Implications for Disease and Therapy

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping.
Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

List of contents

Background.- The Challenges and Opportunities.- Imaging of CNS Systems: Importance for Drug Development.- Imaging Approaches.- Anatomical Imaging: Volumetric Analysis.- Diffusion Tensor Imaging and Drug Development.- Functional Magnetic Resonance Imaging in Drug Development.- Magnetic Resonance Imaging of Pharmacological Systems.- Molecular Imaging: Basic Approaches.- Chemical Imaging: Magnetic Resonance Spectroscopy: The Basics.- Imaging CNS Drug Action.- Animal Imaging.- Incorporating Functional MRI into Clinical Pharmacology Trials.- Imaging Placebo Responses in the Brain.- Structural Imaging of Drug Actions in Neurodegenerative Diseases.- Molecular Imaging of the CNS: Drug Actions.- Imaging CNS Disease States.- Translational MRI in CNS Drug Discovery.- In Vivo Mouse Imaging and Spectroscopy in Drug Discovery.- Neuroimaging in Understanding Chronic Pain Mechanisms and the Development of New Therapies.- Neuroimaging Human Drug Addiction.- Anxiety: Uncover Roles of Stress Related Genes by Imaging Genetics.- Imaging CNS Disease States: Alzheimer's Disease.- Brain Development and CNS Plasticity.- Imaging in CNS Disease States: PTSD.- Integrative Processes.- Integrative Processes: Neuroscience Clinical Imaging Biomarkers.- Reasons to Believe: The Potential of Imaging in CNS Drug Development.

About the author

David Borsook, MD, Ph.D., trained in medicine and neurobiology at the University of the Witwatersrand, Medical School, Johannesburg, South Africa. He graduated in 1980. Following his internship he trained in Neurology at Boston City Hospital and then was the first Pain Fellow at the Massachusetts General Hospital, Department of Neurology. He subsequently was the Director of the Pain Center at the Hospital from 1994 2004. He has completed doctoral studies in Neurobiology and later started the Pain Imaging Program in the Department of Radiology at Massachusetts General Hospital. In 2002 he led an effort to cofound a Biotech Descartes Therapeutics Inc, with his colleague Lino Becerra Ph.D. to use imaging in drug development, where he was Senior Vice President and Chief Scientific Officer. He currently directs an integrated imaging program Pain Analgesia Imaging Neuroscience (p.a.i.n.) Group at three Harvard Medical School Affiliated Hospitals, Massachusetts General Hospital, McLean Hospital and Children s Hospital Boston. A component of this is a consortium of pharmaceutical and academic centers involved in the evaluation of fMRI in drug development known as ICD (Imaging Consortium for Drug Development). He has participated in a number of NIH meetings on future directions of pain research. His research is supported by grants from the National Institutes of Health, Foundations and Pharamaceutical Companies interested in the use of imaging in defining pain phenotype. He has published over 85 papers that include various aspects of pain, imaging in pain and analgesia. He is married with sons living in Concord Massachusetts.

Dr. Lino Becerra Ph.D., is Lecturer in Psychiatry at Harvard Medical School, he has co-appointments in the Departments of Psychiatry at McLean Hospital and Massachusetts General Hospital (MGH), and Radiology at MGH. He's the Director of the Imaging and Analysis Group at the Brain Imaging Center, McLean Hospital; and Co-Director of the Imaging Consortium for Drug Development (ICD) and the Pain Imaging and Analgesics Neuroscience Group (P.A.I.N. Group) at the same institution. Dr. Becerra was a co-founder of Descartes Therapeutics Inc., a biotech company dedicated to the development of drugs for chronic pain patients. Dr. Becerra's research interests are focused on the optimization of functional imaging for its utilization in drug development, in particular for chronic pain. Dr. Becerra specifically is interested in the translational aspects of drug development through the study of preclinical and clinical early phase trials with the aid of neuroimaging. He is author of over 50 publications, reviews and book chapters appearing in journals such as Neuron, Neuroscience, Journal of Neuroscience, Journal of Neurophysiology, NeuroImage, and European Journal of Pain. Dr. Becerra is a reviewer for these Journals, and also for Biological Psychiatry and Archives of General Psychiatry.

Summary

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping.

Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

Product details

• Assisted by: Lino R. Beccera (Editor), David Borsook (Editor), Edward Bullmore (Editor), Edward Bullmore et al (Editor), Richard J. Hargreaves (Editor), Lin R Beccera (Editor), Lino R Beccera (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2014
• EAN: 9781489984746
• ISBN: 978-1-4899-8474-6
• No. of pages: 396
• Dimensions: 155 mm x 22 mm x 235 mm
• Weight: 635 g
• Illustrations: XVIII, 396 p.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; B, Radiology, Neuroscience, biotechnology, Oncology, Neurosciences, Pharmacology, Biomedical and Life Sciences, Imaging / Radiology, Cancer Research, Biomedical Research, Medical imaging, Pharmacology/Toxicology