Glycoscience and Microbial Adhesion

bacterial carbohydrate recognition are conveyed, covering Gram-positive as well as Gram-negative bacteria, in Chapter 4 Streptococci and Staphylococci, and in Chapter 5, carbohydrate binding specificities of Helicobacter pylori. In Chapter 6, Bitter sweetness of complexity, the collected reflections on mic- bial adhesion are expanded by a perspective on a broader impact of glycosylation on cellular adhesion, motility and regulatory processes, paralleling the complexity of N-glycan structures on cell surfaces. It highlights particularly how structural details of N-glycans have been causally related to pathological scenarios, with a focus on ?(1,6)-N-acetylglucosaminyltransferase. In the final chapter, biofilm formation is reviewed, covering knowledge about structure and biosynthesis of polysaccharide intercellular adhesins (PIAs) which are central to biofilm formation. This comprehensive chapter explains all PIA-related principles of medical device-associated infections. It is our hope, that this collection of expert articles, ranging from structural ch- istry and structural biology to biochemistry and medicine, will be a stimulation and motivation for our colleagues in the life sciences. At the same time, we hope that these reflections on microbial adhesion will awake interest in and promote und- standing of the complex processes associated with the glycocalyx and the multif- eted interactions between the host cell and its guest, as well as the biological consequences resulting from this mutual interplay.

List of contents

Bitter Sweetness of Complexity.- Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections.- Structure, Function, and Assembly of Type 1 Fimbriae.- The Multiple Carbohydrate Binding Specificities of Helicobacter pylori.- Ins and Outs of Microbial Adhesion.- Staphylococcus epidermidis Biofilms: Functional Molecules, Relation to Virulence, and Vaccine Potential.- Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions.

Product details

• Assisted by: Thisb K Lindhorst (Editor), Thisbe K Lindhorst (Editor), Thisbe K. Lindhorst (Editor), Oscarson (Editor), Oscarson (Editor), Stefan Oscarson (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2014
• EAN: 9783642425448
• ISBN: 978-3-642-42544-8
• No. of pages: 186
• Dimensions: 155 mm x 11 mm x 235 mm
• Weight: 314 g
• Illustrations: XI, 186 p.
• Series: Topics in Current Chemistry; Topics in Current Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Biotechnologie, C, Microbiology (non-medical), ORGANIC CHEMISTRY, Mikrobiologie (nicht-medizinisch), biotechnology, microbiology, CARBOHYDRATES, Chemistry and Materials Science, Industrial Microbiology, Applied Microbiology, Carbohydrate Chemistry