Advances in Medicinal Chemistry

Klappentext Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed. Inhaltsverzeichnis Preface. Immunophilins: the next generation. Discovery of ABT-594 and related neuronal nicotinic acetylcholine receptor modulators as analgesic agents: medicinal chemistry and biology. Discovery and preclinical evaluation of novel dopamine partial agonists as antipsychotic agents. Nonpeptide inhibitors of HIV protease.

Product details

• Authors: A. B. Dax Reitz
• Assisted by: S L Dax (Editor), S. L. Dax (Editor), S.L. Dax (Editor), A B Reitz (Editor), A. B. Reitz (Editor), A.B. Reitz (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 27.12.1999
• EAN: 9780762305933
• ISBN: 978-0-7623-0593-3
• No. of pages: 212
• Series: Advances in Medicinal Chemistry; Advances in Medicinal Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; ORGANIC CHEMISTRY, SCIENCE / Life Sciences / Neuroscience, SCIENCE / Chemistry / Organic, Neurosciences, Pharmacology, Cellular biology (cytology)