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Chemical sensors are in high demand for applications as varied as water pollution detection, medical diagnostics, and battlefield air analysis. Designing the next generation of sensors requires an interdisciplinary approach. The book provides a critical analysis of new opportunities in sensor materials research that have been opened up with the use of combinatorial and high-throughput technologies, with emphasis on experimental techniques. For a view of component selection with a more computational perspective, readers may refer to the complementary volume of Integrated Analytical Systems edited by M. Ryan et al., entitled "Computational Methods for Sensor Material Selection".
List of contents
Benefits of Combinatorial Approaches to Sensor Problems.- to Combinatorial Methods for Chemical and Biological Sensors.- Main Concepts of Chemical and Biological Sensing.- Self-Assembled Monolayers and Nanoparticles.- Self-Assembled Monolayers with Molecular Gradients.- Combinatorial Libraries of Fluorescent Monolayers on Glass.- High-Throughput Screening of Vapor Selectivity of Multisize CdSe Nanocrystal/Polymer Composite Films.- Molecular Imprinting.- Computational Design of Molecularly Imprinted Polymers.- Experimental Combinatorial Methods in Molecular Imprinting.- Biological Receptors.- Combinatorially Developed Peptide Receptors for Biosensors.- Combinatorial Libraries of Arrayable Single-Chain Antibodies.- A Modular Strategy for Development of RNA-Based Fluorescent Sensors.- Inorganic Gas-Sensing Materials.- Impedometric Screening of Gas-Sensitive Inorganic Materials.- Design of Selective Gas Sensors Using Combinatorial Solution Deposition of Oxide Semiconductor Films.- Electrochemical Synthesis of Sensing Materials.- Combinatorial Development of Chemosensitive Conductive Polymers.- Robotic Systems for Combinatorial Electrochemistry.- Optical Sensing Materials.- Combinatorial Chemistry for Optical Sensing Applications.- High Throughput Production and Screening Strategies for Creating Advanced Biomaterials and Chemical Sensors.- Diversity-Oriented Fluorescence Library Approach for Novel Sensor Development.- Construction of a Coumarin Library for Development of Fluorescent Sensors.- Mining of New Knowledge on Sensing Materials.- Determination of Quantitative Structure-Property Relationships of Solvent Resistance of Polycarbonate Copolymers Using a Resonant Multisensor System.- Computational Approaches to Design and Evaluation of Chemical Sensing Materials.-Outlook.- Combinatorial Methods for Chemical and Biological Sensors: Outlook.
About the author
Vladimir M. Mirsky is Professor at Regensburg University, Germany. He graduated from Moscow Medical University in 1981 as M.D. in biophysics and went on to study physical chemistry and electrochemistry at the Frumkin Institute of Electrochemistry of the Soviet Academy of Sciences, obtaining his Ph.D. in 1986. He subsequently held an Alexander-von-Humboldt Research Fellowship and a research position at the CNRS Centre of Molecular Biology in France prior to joining the Institute of Analytical Chemistry at Regensburg University in 1995. He editor of two recent books, "Ultrathin Electrochemical Chemo- and Biosensors" and "Combinatorial Methodologies for Development of Chemical and Biological Sensors". His work has led to 18 patents and patent applications as well as some 100 peer-reviewed scientific papers.
Summary
Chemical sensors are in high demand for applications as varied as water pollution detection, medical diagnostics, and battlefield air analysis. Designing the next generation of sensors requires an interdisciplinary approach. The book provides a critical analysis of new opportunities in sensor materials research that have been opened up with the use of combinatorial and high-throughput technologies, with emphasis on experimental techniques. For a view of component selection with a more computational perspective, readers may refer to the complementary volume of Integrated Analytical Systems edited by M. Ryan et al., entitled “Computational Methods for Sensor Material Selection”.
Additional text
From the reviews:
"The present book gives a wide-ranging overview of the applications of combinatorial synthesis to the field of sensor development. … The chapters are organized into seven sections based on techniques for constructing the main sensors … . In summary, this volume offers a carefully picked collection of relevant examples from the field of synthesis of combinatorial sensors. A reader interested in this field and already conversant in the science of sensors will find it a thought-provoking starting point for more in-depth literature research." (Marco Bonizzoni and Eric V. Anslyn, Journal of the American Chemistry Society, Vol. 131 (40), 2009)
Report
From the reviews:
"The present book gives a wide-ranging overview of the applications of combinatorial synthesis to the field of sensor development. ... The chapters are organized into seven sections based on techniques for constructing the main sensors ... . In summary, this volume offers a carefully picked collection of relevant examples from the field of synthesis of combinatorial sensors. A reader interested in this field and already conversant in the science of sensors will find it a thought-provoking starting point for more in-depth literature research." (Marco Bonizzoni and Eric V. Anslyn, Journal of the American Chemistry Society, Vol. 131 (40), 2009)
