Advances in Vascular Medicine

Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with his research group and clinical colleagues, has provided a substantial contribution to this book. In common with our previous book - Vascular Complications in Human Disease: Mechanisms and Consequences published by Springer in 2008, our aim with this book is to highlight some of the established relationships between basic science and clinical medicine, and to outline new and exciting fields of research and practice in vascular biology and pathobiology. There are two sections: Basic Science of Vascular Biology and Clinical Aspects of Vascular Biology. In the first section, dealing with basic science, we have included three important growth areas: "Genetics and Gene Therapy" cover approaches to gene therapy and delivery systems, "Animal Models to Study Vascular Disease" with chapters on animal models of scleroderma, animal models of atherosclerosis, and finally on the endothelin system.

List of contents

Genetics and Gene Therapy.- Oligonucleotide Therapeutics to Treat Dyslipoproteinemia and Atherosclerosis.- Gene Delivery to Cardiovascular Tissue.- Animal Models to Study Vascular Disease.- Animal Models of Scleroderma: From Cellular and Molecular Mechanisms to Novel Antifibrotic Strategies.- Animal Models of Atherosclerosis.- Animal Models of the Endothelin System.- Molecules and Mediators and Therapeutic Applications.- Endothelin-1 and Systemic Sclerosis.- The Role of the Homeodomain Transcription Factor Nkx2-5 in the Cardiovascular System.- Cell Therapy for Cardiovascular Disease.- Tissue-Engineered Vascular Substitutes: New Models Toward Successful Small Diameter Grafts.- Role of Perivascular Adipose Tissue in Vascular Function.- Endothelium: Dysfunction and Repair.- Clinical Aspects of Vascular Biology.- Chronic Thromboembolic Pulmonary Hypertension.- Pathophysiology of Chronic Thromboembolic Pulmonary Hypertension (CTEPH).- Surgical Management of Chronic Thromboembolic Pulmonary Hypertension (CTEPH).- Imaging in Acute and Chronic Pulmonary Thromboembolic Disease.- Vascular Disease in Connective Tissue Diseases.- PAH in CTD - Clinical Trials Criteria and Performance.- Disease Progression in Systemic Sclerosis Associated Pulmonary Arterial Hypertension.- Connective Tissue Disease Associated Pulmonary Arterial Hypertension: Special Cases?.- Advances in Vascular Medicine.- Cardiovascular Disease.- Coronary Heart Disease in Women.- Recent Strategies to Improve Graft Performance in Patients Undergoing Coronary Artery Bypass Surgery. Are Best Results Achieved by Improved Surgical Techniques of Graft Preparation?.- Cardiovascular Risk Prediction by Measurement of Arterial Elastic Properties and Wall Thickness.- The Metabolic Syndrome.

About the author

Dr Clive Handler BSc, MD, MRCP,FACC, FESC is an Honorary Consultant in the National Pulmonary Hypertension Unit at The Royal Free Hospital, London and Consultant Cardiologist at Highgate Hospital, London. He was previously Consultant Cardiologist at Northwick Park and St Mary's Hospitals, London. He trained at Guy's Hospital Medical School and at St Luke's Hospital Milwaukee, University of Wisconsin.

Dr Gerry Coghlan MD, FRCP is Consultant Cardiologist and Director of the National Pulmonary Hypertension Unit at the Royal Free Hospital. He trained in Dublin and at Harefield and the Royal Free Hospitals. He is an international authority on Pulmonary Hypertension but has wide interests in all aspects of the management of coronary heart disease and angioplasty. He has written several books with Dr Clive Handler as well as scientific papers on pulmonary hypertension and other aspects of cardiology.

Summary

This book highlights some of the relationships between basic science and clinical medicine, and it reviews research and clinical practice methods and outcomes in vascular biology and pathobiology. It contains nearly eighty illustrations, most in color.

Additional text

From the reviews:

“This collection presents focused discussions on the current understanding of endothelial function, atherosclerosis, pulmonary hypertension, systemic sclerosis, and chronic thromboembolic disease. … It is directed at a diverse audience of scientists and physicians who specialize in vascular disease. … provides clinical insight, which is useful for basic scientists and clinical researchers. It also offers vascular surgeons, cardiologists, rheumatologists, and vascular medicine physicians … . The high quality writing offers stimulating and relevant ideas to both investigators and clinicians.” (Judith L. Meadows, Doody’s Review Service, May, 2010)

Report

From the reviews: "This collection presents focused discussions on the current understanding of endothelial function, atherosclerosis, pulmonary hypertension, systemic sclerosis, and chronic thromboembolic disease. ... It is directed at a diverse audience of scientists and physicians who specialize in vascular disease. ... provides clinical insight, which is useful for basic scientists and clinical researchers. It also offers vascular surgeons, cardiologists, rheumatologists, and vascular medicine physicians ... . The high quality writing offers stimulating and relevant ideas to both investigators and clinicians." (Judith L. Meadows, Doody's Review Service, May, 2010)

Product details

• Assisted by: David Abraham (Editor), Gerry Coghlan (Editor), Michael Dashwood (Editor), Michael Dashwood et al (Editor), Cliv Handler (Editor), Clive Handler (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2014
• EAN: 9781447157632
• ISBN: 978-1-4471-5763-2
• No. of pages: 451
• Dimensions: 155 mm x 25 mm x 235 mm
• Weight: 718 g
• Illustrations: XVIII, 451 p.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; B, Medicine, Surgery, HUMAN PHYSIOLOGY, Cardiology, PHYSIOLOGY, INTERNAL MEDICINE, vascular surgery, Cardiac Surgery, Cardiothoracic surgery