Osteoporosis - Pathophysiology and Clinical Management

In Osteoporosis: Pathophysiology and Clinical Management, leading clinicians and researchers join forces to illuminate in coupled chapters all the major scientific and clinical aspects of osteoporosis. On the basic science side, topics range from the genetics of osteoporosis and bone turnover markers, to androgen action in bone, to the basic biology of estrogen and bone. On the clinical side the authors present the latest thinking about the use of bone densitometry in treatment, the use of vitamin D and its metabolites, and the clinical utilization of salmon calcitonin, as well as parathyroid and bisphosphonate therapies, SERMs, and other important treatments. With varying degrees of osteoporosis found in one of every four women older than 45 years of age and in nine out of ten women older than 75, as well as in men, osteoporosis is clearly a widespread disease with important health and economic impacts. It is also scientifically complex. In Osteoporosis: Pathophysiology and Clinical Management, leading clinicians and researchers join forces to illuminate in coupled chapters all the major scientific and clinical aspects of osteoporosis. By uniquely coupling basic and clinical chapters, the book illustrates the critical interdependence of investigators and practitioners. Traditional issues such as calcium supplementation and exercise are juxtaposed with state-of-the-art updates on molecular pharmacology and imaging. On the basic science side, topics range from the genetics of osteoporosis and bone turnover markers, to androgen action in bone, to the basic biology of estrogen and bone. On the clinical side the authors present the latest thinking about the use of bone densitometry in treatment, the use of vitamin D and its metabolites, and the clinical utilization of salmon calcitonin, as well as parathyroid and bisphosphonate therapies, SERMs, and other important treatments.
Unique in its integration of basic science and clinical practice, Osteoporosis: Pathophysiology and Clinical Management reveals the great progress that has occurred in the field, providing basic scientists with a clear view of the clinical state-of-the-art, and practicing physicians with a deeper understanding of the complex biology involved.

List of contents

Human and Animal Studies of the Genetics of Osteoporosis
Robert F. Klein and Tatiana Foroud
The Genetics of Osteoporosis: Progress in Mice, not Man
Ego Seeman
Peak Bone Mass Acquisition
Jean-Philippe Bonjour and René Rizzoli
Peripheral Bone Mineral Assessment of the Axial Skeleton: Technical Aspects
Thomas F. Lang and Jeffrey Duryea
Use of Bone Densitometry in the Clinical Management of Osteoporosis
John Shepherd, Chris Njeh, and Harry K. Genant
Technical Aspects of Skeletal Assessment Using Quantitative Ultrasound
Mary L. Bouxsein
Clinical Aspects of Skeletal Assessment with Ultrasound
Daniel T. Baran
Molecular Markers of Bone Turnover: Basic and Analytical Aspects
Berthold Fohr, Henning W. Woitge, and Markus J. Seibel
Bone Turnover Markers: Their Place in the Investigation of Osteoporosis
Richard Eastell and Penny R. Bainbridge
Mechanical Influences on Bone Mass and Morphology: Investigating How Exercise May Regulate Adaptation in the Skeleton
Stefan Judex and Clinton Rubin
Exercise in the Prevention of Osteoporosis-Related Fractures
Christine M. Snow and Belinda R. Beck
The Physiology and Cell Biology of Calcium Transport in Relation to the Development of Osteoporosis
Richard L. Prince and Paul Glendenning
Calcium, Bone, and Life
Robert P. Heaney
Clinical Aspects of the Use of Vitamin D and Its Metabolites in Osteoporosis
Ian R. Reid
The Basic Biology of Estrogen and Bone
Russell T. Turner, David Rickard, Thomas C. Spelsberg, and Jean D. Sibonga
Clinical Trials of Estrogen and SERMs on Bone Markers, Bone Mineral Density, and Fractures
Lorraine A. Fitzpatrick
Androgen Action in Bone: Basic Cellular and Molecular Aspects
Kristine M. Wiren
Androgens and Skeletal Homeostasis: Potential ClinicalImplications of Animal Data
Dirk Vanderschueren, Liesbeth Vandenput, Johannes V. Swinnen, Steven Boonen, and Roger Bouillon
Gonadal Steroids and the Skeleton in Men: Clinical Aspects
Benjamin Z. Leder and Joel S. Finkelstein
Basic Aspects of Calcitonin in Skeletal Health
Carlo Gennari
Clinical Utilization of Salmon Calcitonin in the Treatment of Osteoporosis: Rationale, Supportive Data, and Considerations for the Future
Charles H. Chesnut, III and Moïse Azria
The Mechanism of Action of Nitrogen-Containing Bisphosphonates
Alfred A. Reszka and Gideon A. Rodan
Bisphosphonate Treatment of Osteoporosis
Nelson B. Watts
Basic Aspects of PTH in Skeletal Health
Janet M. Hock
Parathyroid Hormone as a Therapy for Osteoporosis
Mishaela R. Rubin and John P. Bilezikian
The Cellular and Molecular Aspects of Immunosuppressant Osteoporosis
Mone Zaidi, Jameel Iqbal, Angela M. Inzerillo, Etsuko Abe, Li Sun, and Solomon Epstein
Transplantation Osteoporosis
Elizabeth Shane
The Molecular Pharmacology of Osteoporosis
Jameel Iqbal, Angela Inzerillo, Baljit S. Moonga, and Mone Zaidi
Index

Product details

• Assisted by: Michael Bliziotes (Editor), Eric S. Orwoll (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 12.04.2012
• EAN: 9780896039339
• ISBN: 978-0-89603-933-9
• No. of pages: 615
• Weight: 2 g
• Illustrations: 53 SW-Abb.
• Series: Contemporary Endocrinology; Contemporary Endocrinology
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine