Fr. 237.00

Epigenetic Alterations in Oncogenesis

English · Paperback / Softback

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Description

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The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means "above" genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

List of contents

Preface.- Section I: Epigenetic Marks and Mechanisms.- DNA methyltransferases (DNMTs), DNA damage repair, and cancer.- DNA hypomethylation and hemimethylation in cancer.- Ten Eleven Translocation (TET) Enzymes and 5-hydroxymethylation in Mammalian Development and Cancer.- Altered histone modifications in cancer.- Nucleosome occupancy and gene regulation during tumorigenesis.- Section II: The Impact of Epigenetic Alterations on Cancer Biology.- Epigenetic regulation of miRNAs in cancer.- DNA hypomethylation and activation of germline-specific genes in cancer.- APC and DNA demethylation in cell fate specification and intestinal cancer.- Epigenetic changes during cell transformation.- Epigenetic reprogramming of mesenchymal stem cells.- Section III: Clinical Implications and Analysis Methods.- Environmental toxicants, epigenetics, and cancer.- Blood derived DNA methylation markers of cancer risk.- Epigenetic therapies in MDS and AML.- Epigenetic targeting therapies to overcome chemotherapy resistance.- Methods for cancer epigenome analysis.- Index

Summary

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Additional text

From the reviews:
“This well-illustrated book is an excellent source of cutting-edge scientific information on epigenetic marks such as cytosine methylation and cytosine hydroxymethylation, histone tail modifications, histone variants and nucleosome positional information, recognized to play a fundamental role in cancer development and progression. … There are very few books available on this subject. This one will be very useful for students and researchers interested in knowing more about epigenetic alterations in oncogenesis.” (Omer Iqbal, Doody’s Book Reviews, August, 2013)

Report

From the reviews:
"This well-illustrated book is an excellent source of cutting-edge scientific information on epigenetic marks such as cytosine methylation and cytosine hydroxymethylation, histone tail modifications, histone variants and nucleosome positional information, recognized to play a fundamental role in cancer development and progression. ... There are very few books available on this subject. This one will be very useful for students and researchers interested in knowing more about epigenetic alterations in oncogenesis." (Omer Iqbal, Doody's Book Reviews, August, 2013)

Product details

Assisted by Adam R. Karpf (Editor), Ada R Karpf (Editor), Adam R Karpf (Editor)
Publisher Springer, Berlin
 
Languages English
Product format Paperback / Softback
Released 01.01.2014
 
EAN 9781489985583
ISBN 978-1-4899-8558-3
No. of pages 348
Dimensions 155 mm x 19 mm x 235 mm
Weight 557 g
Illustrations XVI, 348 p.
Subjects Natural sciences, medicine, IT, technology > Medicine > Clinical medicine

B, INTERNAL MEDICINE, Oncology, Human Genetics, Biomedical and Life Sciences, Cancer Research, Medical Genetics, Biomedical Research

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