Dna in Supramolecular Chemistry and Nanotechnology

Informationen zum Autor EUGEN STULZ School of Chemistry, University of Southampton, UK GUIDO H. CLEVER Department for Inorganic Chemistry, Georg-August University, Germany Klappentext This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices.The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures.Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research. Zusammenfassung This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Inhaltsverzeichnis List of Contributors xv Preface xix Part I (Non-) Covalently Modified DNA with Novel Functions 1 1.1 DNA-Based Construction of Molecular Photonic Devices 3 1.1.1 Introduction 3 1.1.2 Using DNA as a template to construct discrete optoelectronic nanostructures 5 1.1.3 Assembly of photonic arrays based on the molecular recognition of single-stranded DNA templates 7 1.1.4 Assembly of photonic arrays based on the molecular recognition of double-stranded DNA templates 10 1.1.5 Towards the construction of photonic devices 13 1.1.6 Outlook 13 References 15 1.2 ¿-Conjugated DNA Binders: Optoelectronics, Molecular Diagnostics and Therapeutics 22 1.2.1 ¿-Conjugated compounds 22 1.2.2 DNA binders for different applications 23 1.2.3 Targeting duplex DNA 27 1.2.4 Examples of ¿-conjugated compounds interacting with hybrid duplexes and higher order nucleic acid structures 32 1.2.5 Conclusions 33 References 34 1.3 Metal Ion- and Perylene Diimide-Mediated DNA Architectures 38 1.3.1 Introduction 38 1.3.2 Metal ion complexes as DNA modifications: hydroquinoline and terpyridine 39 1.3.3 Perylene diimide-based DNA architectures 42 1.3.4 Conclusions 49 References 49 1.4 DNA with Metal-Mediated Base Pairs 52 1.4.1 Introduction 52 1.4.2 Metal-mediated base pairs with natural nucleobases 53 1.4.3 Metal-mediated base pairs with artificial nucleobases 54 1.4.4 Outlook 61 References 61 1.5 Metal-Aided Construction of Unusual DNA Structural Motifs 65 1.5.1 Introduction 65 1.5.2 DNA duplexes containing metal-mediated base pairs 66 1.5.3 Metal-aided formation of triple-stranded structures 69 1.5.4 Metal-aided formation of four-stranded structures 71 1.5.5 Metal-aided formation of DNA junction structures 73 1.5.6 Summary and outlook 75 References 75 Part II DNA Wires and Electron Transport Through DNA 79 2.1 Gating Electrical Transport Throug...

List of contents

List of Contributors xv
 
Preface xix
 
Part I (Non-) Covalently Modified DNA with Novel Functions 1
 
1.1 DNA-Based Construction of Molecular Photonic Devices 3
 
1.1.1 Introduction 3
 
1.1.2 Using DNA as a template to construct discrete optoelectronic nanostructures 5
 
1.1.3 Assembly of photonic arrays based on the molecular recognition of single-stranded DNA templates 7
 
1.1.4 Assembly of photonic arrays based on the molecular recognition of double-stranded DNA templates 10
 
1.1.5 Towards the construction of photonic devices 13
 
1.1.6 Outlook 13
 
References 15
 
1.2 pi-Conjugated DNA Binders: Optoelectronics, Molecular Diagnostics and Therapeutics 22
 
1.2.1 pi-Conjugated compounds 22
 
1.2.2 DNA binders for different applications 23
 
1.2.3 Targeting duplex DNA 27
 
1.2.4 Examples of pi-conjugated compounds interacting with hybrid duplexes and higher order nucleic acid structures 32
 
1.2.5 Conclusions 33
 
References 34
 
1.3 Metal Ion- and Perylene Diimide-Mediated DNA Architectures 38
 
1.3.1 Introduction 38
 
1.3.2 Metal ion complexes as DNA modifications: hydroquinoline and terpyridine 39
 
1.3.3 Perylene diimide-based DNA architectures 42
 
1.3.4 Conclusions 49
 
References 49
 
1.4 DNA with Metal-Mediated Base Pairs 52
 
1.4.1 Introduction 52
 
1.4.2 Metal-mediated base pairs with natural nucleobases 53
 
1.4.3 Metal-mediated base pairs with artificial nucleobases 54
 
1.4.4 Outlook 61
 
References 61
 
1.5 Metal-Aided Construction of Unusual DNA Structural Motifs 65
 
1.5.1 Introduction 65
 
1.5.2 DNA duplexes containing metal-mediated base pairs 66
 
1.5.3 Metal-aided formation of triple-stranded structures 69
 
1.5.4 Metal-aided formation of four-stranded structures 71
 
1.5.5 Metal-aided formation of DNA junction structures 73
 
1.5.6 Summary and outlook 75
 
References 75
 
Part II DNA Wires and Electron Transport Through DNA 79
 
2.1 Gating Electrical Transport Through DNA 81
 
2.1.1 Introduction 81
 
2.1.2 DNA structure 82
 
2.1.3 Direct electrical measurements of DNA 82
 
2.1.4 Gate modulation of current flow in DNA 84
 
2.1.5 DNA transistors 86
 
2.1.6 Summary and outlook 92
 
References 92
 
2.2 Electrical Conductance of DNA Oligomers -- A Review of Experimental Results 94
 
2.2.1 Introduction 94
 
2.2.2 DNA structures 95
 
2.2.3 Scanning probe microscopy 95
 
2.2.4 Lithographically defined junctions 98
 
2.2.5 Conclusions 101
 
References 102
 
2.3 DNA Sensors Using DNA Charge Transport Chemistry 105
 
2.3.1 Introduction 105
 
2.3.2 DNA-functionalized electrochemical sensors 107
 
2.3.3 Detection of DNA-binding proteins 111
 
2.3.4 DNA CT within the cell 115
 
2.3.5 Conclusions 117
 
Acknowledgements 117
 
References 117
 
2.4 Charge Transfer in Non-B DNA with a Tetraplex Structure 121
 
2.4.1 Introduction 121
 
2.4.2 CT in dsDNA (B-DNA) 122
 
2.4.3 CT in non-B DNA with a tetraplex structure 123
 
2.4.4 Conclusions 132
 
Acknowledgments 132
 
References 132
 
Part III Oligonucleotides in Sensing and Diagnostic Applications 137
 
3.1 Development of Electrochemical Sensors for DNA Analysis 139
 
3.1.1 Introduction 139
 
3.1.2 Genosensors based on direct electrocactivity of nucleic bases 140
 
3.1.3 Genosensors base

Product details

• Authors: Guido H Clever, Guido H. Clever, Guido H. (Department for Inorganic Chemist Clever, E Stulz, Euge Stulz, Eugen Stulz, Eugen (School of Chemistry Stulz, Eugen Clever Stulz
• Assisted by: Guido H. Clever (Editor), Clever Guido H. (Editor), H Clever (Editor), H Clever (Editor), Euge Stulz (Editor), Eugen Stulz (Editor), Stulz Eugen (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 18.09.2015
• EAN: 9781118696866
• ISBN: 978-1-118-69686-6
• No. of pages: 528
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, Nanotechnologie, DNS, chemistry, Desoxyribonukleinsäure, SUPRAMOLECULAR CHEMISTRY, supramolekulare Chemie, Biomaterial, Nanotechnology, Biomedical engineering, Biomaterials, Biomedizintechnik, Allg. Nanotechnologie, Biomaterialien