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Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules, including cell membrane proteins and ion channels, are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. The book reveals the state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
List of contents
The DEG/ENaC Family.- The Role of DEG/ENaC Ion Channels in Sensory Mechanotransduction.- ASICs Function as Cardiac Lactic Acid Sensors During Myocardial Ischemia.- Molecular Components of Neural Sensory Transduction.- The TRP Family.- TRP Channels as Molecular Sensors of Physical Stimuli in the Cardiovascular System.- TRPV1 in Central Cardiovascular Control.- TRPV1 as a Molecular Transducer for Salt and Water Homeostasis.- Functional Interaction Between ATP and TRPV1 Receptors.- TRPV4 and Hypotonic Stress.- Other Ion Channels and Biosensors.- Ion Channels in Shear Stress Sensing in Vascular Endothelium.- Redox Signaling in Oxygen Sensing by Vessels.- Impedance Spectroscopy and Quartz Crystal Microbalance.
Summary
Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules, including cell membrane proteins and ion channels, are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. The book reveals the state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
