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This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).
List of contents
Part One - From "delayed allergy reaction" to the "immunologic constant or rejection"1. Ena Wang and Francesco M MarincolaPart Two - The immune biology of rejection; basic principles2. Experimental models of rejection - Anil Shanker A3. Cancer and Inflammation - Alberto Mantovani4. The immunologic switch - Giorgio Trinchieri5. The angiogenic switch - Douglas Noonan6. Chemokines and cytotoxic effector molecules in rejection - Alan Krensky7. Immune cell activation: the clinical perspective - David F StroncekPart Three - Circulating patterns associated with chronic and acute immune pathology8. Immune signatures detectable in peripheral lymphocytes: a modular view - Damien Chaussabel9. Immune signatures associated with unresolving compared to resolving infections: the HCV model - Robert E Lanford10. Immune signatures associated with unresolving infections: the HIV model - Luigi Buonaguro11. Immune signatures associated with the cancer-bearing status - Peter P LeePart Four - Tissue-specific patterns associated with chronic inflammatory processes12. Signatures associated with destructive autoimmune pathologies - Steve Jacobson13. Predictors of favorable outcome in cancer - Zoltan Pos14. Other predictors of outcome - George Coukos15. Transcriptional profiling of melanoma as a potential predictive biomarker for response to immunotherapy - Thomas F. Gajewski16. Predictors of allograft rejection - Sarwal MinniePart Five - Signatures associated with acute rejection17. Graft vs Host - Fran Hakim18. Tumor rejection- Ena Wang19. Allograft rejection - Davide Bedognetti
Summary
This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).
