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Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.
List of contents
Preface.- PART 1. The Pathogenesis of Medical Device associated Infection.- Chapter 1: Biomaterial associated infection: a perspective from the clinic.- Chapter 2: Staphylococcus epidermidis in biomaterial associated infection.- Chapter 3: Staphylococcal virulence factors.- Chapter 4: Propionibacterium acnes: a new emerging pathogen in biomaterial associated infection.- Chapter 5: Bridging the gap between in vitro and in vivo testing for Biomaterial associated infection.- Chapter 6: Biomaterial-dependent characteristics of the foreign body response and S. epidermidis biofilm interactions.- Chapter 7: Dendritic cell-biomaterial interactions: implications for the onset and development of the foreign body response.- Chapter 8: Tissue Colonisation in Biomaterial-Associated Infection.- Chapter 9: Treatment options for medical device associated infection.- Chapter 10: Novel antimicrobial strategies: honey and antimicrobial peptides.- Chapter 11: Infections associated with implanted dental devices.- Chapter 12: Animal models of orthopedic implant related infection.- PART 2: Biomaterial-based Strategies to Reduce Medical Device Associated Infection.- Chapter 13: Antimicrobial medical devices in preclinical development and clinical use.- Chapter 14: Silver containing biomaterials.- Chapter 15: Quaternary ammonium Compounds.- Chapter 16: Anti-adhesive and Antibacterial Polymer Brushes.- PART 3: Clinical applications, case studies.- Chapter 17: Orthopaedic device design and antibiotic coatings reduce infection rates.- Chapter 18: The indwelling bladder catheter: attempts to prevent infection and the development of bacterial biofilms.- Chapter 19: Antimicrobial-Modified Vascular Catheters.- Chapter 20: Topical Antimicrobial Containing Biomaterials for Peri-Implant Infections in the Oral Cavity.- Chapter 21: Preventive Strategies in VAP: Focus on Silver-Coated Endotracheal Tubes.- Index.
Summary
Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.
