An Efficient Pyrimidine Scaffolds against Bacterial Strains - Pyrimidine Derivatives

A series of novel 2-(substituted benzylidene)-7-(4-bromophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-ones were synthesized by using established methods and were characterized by IR, 1H NMR and Mass spectroscopy in order to confirm their formation. These compounds were synthesized to evaluate their antitubercular, antibacterial and antifungal potency. Docking studies revealed the importance of functional groups and its different biological action. They were found to be potent against Mycobacterium tuberculosis H37Ra strain, also potent against Gram +ve, Gram -ve and fungal strains

About the author

Dr. T. Panneerselvam Is working as an Associate Professor in Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu. He earned Young Faculty Award 2014 and he has 08 years of teaching and research experience. His research has focused on the Design, Synthesis, and Analytical/Biological Screening of Novel Heterocyclic Derivatives.

Product details

• Authors: Vijaysarathy D Phadte, Vijaysarathy D. Phadte, Theivendre Panneer Selvam, Theivendren Panneer Selvam, Vijaysarathy D. Phadte, Silveira Karyn Valzita
• Publisher: LAP Lambert Academic Publishing
• Languages: English
• Product format: Paperback / Softback
• Released: 15.07.2013
• EAN: 9783659428517
• ISBN: 978-3-659-42851-7
• No. of pages: 168
• Subject: Natural sciences, medicine, IT, technology > Medicine > Pharmacy