Population balance modelling of non-native protein aggregation - Kinetics of protein aggregation

A comprehensive modelling methodology for analysis of the kinetics of non-native protein aggregation based on general population balance model within the Extended Lumry-Eyring framework is presented. The population balance model is formulated in terms of key parameters, describing relative importance of (un)folding and aggregation kinetics of a protein in diffusion-driven conditions. Both the analytical and numerical solution provide a detailed insight on the intrinsic aggregation kinetics via time-dependent evolution of a variety of experimentally measurable quantities.

About the author

Dr. Peter Grancic obtained his PhD in 2009 investigating the non-native protein aggregation at the University of Strathclyde (Glasgow, Scotland). Following a 3 year position at the Chemical Robotics Laboratory (Prague, Czech Republic). Since 2012 he works as a postdoctoral research associate at the Radboud University (Nijmegen, The Netherlands).

Product details

• Authors: Peter Grancic
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 24.08.2012
• EAN: 9783659212031
• ISBN: 978-3-659-21203-1
• No. of pages: 108
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Physical chemistry