regulation of 5-HT1A receptor gene - role of CC2D1B/Freud-2 transcription factor

The serotonin 1A receptor (5-HT) is expressed presynaptically on raphe neurons and works as an inhibitory autoreceptor. It is also expressed postsynaptically in limbic and cortical areas involved in mood and emotional regulation. Alteration in expression and function of 5-HT 1A receptors is believed play an important role in etiopathology and treatment of mood disorders such as major depression. Here in this book we reviewed transcriptional regulation of 5-HT1A receptor gene and introduced a novel regulator which acts on expression of 5-HT1A receptor postsynaptically.

About the author

Assistant professor MD, PhD Doctorate of Philosophy (PhD) in Neuroscience/cellular and molecular medicine Post-doctoral fellow in Neuroscience Doctor in medicine graduated from University of Ottawa, Canada Scientific evaluator at Health Canada 10 years experience as a researcher/scientist of health network Member of medical council of Iran

Product details

• Authors: Mahmoudreza Hadjighassem
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 20.05.2011
• EAN: 9783844332179
• ISBN: 978-3-8443-3217-9
• No. of pages: 184
• Subject: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering