Strategies in design of Alzheimer's disease drugs - A theoretical chemistry perspective

This study describes ab initio quantum mechanical calculations on peptidic and peptidomimetic compounds as preventive drugs for Alzheimer's disease. De novo designing has been undertaken based on energetic aspects of mechanism involved. Designed compounds have been subjected to in silico testing. Study also suggests a conformationally controlled mechanism for BACE inhibitors. Reduced molecular weight lead compounds of preventive type with drug like features have been proposed.

About the author

Dr. Arpita Yadav, M.Sc., Ph.D., Assistant Professor Department of Chemistry, University Institute of Engineering and Technology, C.S.J.M. University, Kanpur 208024, India Email:[e-mail] Research interests: Computer aided drug designing using quantum mechanical techniques, Peptidomimetic drug delivery systems

Product details

• Authors: Minakshi Sonker, Arpit Yadav, Arpita Yadav
• Publisher: LAP Lambert Academic Publishing
• Languages: English, German
• Product format: Paperback / Softback
• Released: 03.02.2011
• EAN: 9783843389037
• ISBN: 978-3-8433-8903-7
• No. of pages: 116
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Theoretical chemistry