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Informationen zum Autor Dr Sam Thiagalingam is an Associate Professor of Genetics and Genomics, Medicine and Pathology at the Boston University School of Medicine. He played a major role in establishing an association between genomic instability and loss of heterozygosity (LOH) in human cancers. He was the first to show that SMAD4 inactivation is a critical event during the late stages of colon cancer progression and sustained TGFß signaling events are required to maintain epigenetic memory during breast cancer progression. Dr Thiagalingam also proposed a simple minded multi-modular molecular network (MMMN) cancer progression model as a road map to visualize the various gene alterations in modules of networks of pathways. His long-term goal is to identify novel cancer biomarkers and therapeutic targets by contributing to the 'big picture' of interconnected networks of events that mediate cancer progression to metastasis using breast and colon cancers as the model systems. Klappentext An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.Cancer is a complex group of diseases with many possible causes. Bringing together state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Inhaltsverzeichnis Contributors; Preface; Part I. Introduction to Modular Organization of the Networks of Gene Functions and Cancer: 1. Systems biology of cancer progression Sam Thiagalingam; 2. Lessons from cancer genome sequencing Antoine Ho and Jeremy S. Edwards; 3. Application of bioinformatics to analyze the expression of tissue-specific and housekeeping genes in cancer Xijin Ge; Part II. Alterations in the Regulatory Networks of Fundamental Cellular and Molecular Events in Cancer: 4. Events at DNA replication origins and genome stability Kathleen R. Nevis, Kimberly L. Raiford, Cyrus Vaziri and Jeanette Gowen Cook; 5. Systems biology approaches bring new insights in the understanding of global gene regulatory mechanisms and their deregulation in cancer Arnaud Krebs and László Tora; 6. Regulation and dysregulation of protein synthesis in cancer cells Michael J. Clemens, Androulla Elia and Simon J. Morley; Part III. Networks of Events Responsible for the Manifestation of Aberrant Genetic and Epigenetic Codes in Cancer: 7. Genomic instability and carcinogenesis Mark E. Burkard and Prasad V. Jallepalli; 8. Epigenomic code José Ignacio Martín-Subero and Manel Esteller; 9. MicroRNA epigenetic systems and cancer Holly Lewis and Aurora Esquela-Kerscher; 10. Dietary and environmental influences on the genomic and epigenomic codes in cancer Hamid Abdolmaleky and Jin-Rong Zhou; Part IV. Functional Networks of Events that Modulate Phenotypic Manifestation of Cancer: 11. Regulatory signaling networks in cell transformation and cancer Yashaswi Shrestha and William C. Hahn; 12. RAS signaling networks Douglas Faller; 13. The PI3K pathway in cancer Amancio Carnero; 14. TGFß and BMP signaling in cancer Panagiotis Papageorgis, Arthur W. Lambert, Sait Ozturk and Sam Thiagalingam; 15. The Wnt signaling network in cancer Johanna Apfel, Jignesh R. Parikh, Patricia Reischmann, Rob M. Ewing, Oliver Müller, Yu Xia and Isabel Dominguez; 16. Apoptotic pathways and cancer Jian Yu and Lin Zhang; 17. Molecular links between inflammation and cancer Paola Allavena, Giovanni Germano and Alberto Mantovani; 18. Cancer metastasis Sait Ozturk, Arthur W. Lambert, Chen Khuan Wong, Panagiotis Papageorgis and Sam Thiagalingam; 19. Cancer metabolism Dimitrios Anastasiou, Jason W. Locasale and Matthew G. Vander Heiden; 20. Tumor microenvironment: blood vascular system in cancer metastasis Shantibhusan Senapati, Rakesh K. Singh and Surinder K. Batra; Part V. Current State of the Ev...
