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Non-steroidal anti-inflammatory drugs (NSAIDs) are among the mostfrequently prescribed drugs in the Western world. During the past decade a large number of new compounds were marketed, some of which had to be withdrawn after a short while because of adverse drug reactions. These experiences led to an under standing that a complete picture of the safety of these drugs can only be obtained after their introduction into the marketplace. Differentmethods ofpost-marketing surveillance (PMS) serve as important tools for monitoring the frequency of adverse reactions and for generating and corroborating hypotheses. Experience with PMS has thusfar been quite limited in Germany. In 1987 a non-profit organization, "Verein zur Langzeituntersuchung von Arzneimittel wirkungen auf dem Gebiet der Rheumatologie e. V. " (VLAR) was founded by interested physicians and pharmacologists to raise funds and perform investiga tions on the safety of NSAIDs. The first project by the VLAR, SPALA ("Safety Profile of Antirheumatics in Long-Term Administration"), was sponsored by F. Hoffmann-La Roche AG (Basel, Switzerland). In July 1990, when the project was successfully terminated, almost 30,000 patients had been completely docu mented and their medical records entered into a computer for subsequent review by a select panel of experts with experience in monitoring adverse reactions to NSAIDs. The comments, criticisms, and ideas of these experts were brought togetherat a symposium organized by the VLAR at the Klinikum Steglitz (Berlin, Germany) on 12 October 1990.
List of contents
Spontaneous Reporting Systems: Benefits and Pitfalls when Interpreting Safety Data of Non-Steroidal Anti-Inflammatory Drugs.- Drug Utilization Studies: A Useful Tool for the Safety Evaluation of Non-Steroidal Anti-Inflammatory Drugs?.- Post-Marketing Surveillance as an Instrument of Adverse Drug Reaction Monitoring.- Non-Steroidal Anti-Inflammatory Drugs: Epidemiological Studies of Adverse Reactions.- The SPALA Project - An Intensive Monitoring System for Non-Steroidal Anti-Inflammatory Drugs.- Toxicity Analysis of Mild Analgesics in Clinical Use.- Gastrointestinal Tract Toxicity - A Risk Factor for Non-Steroidal Anti-Inflammatory Therapy.- Incidence of Mild and Severe Skin Reactions Associated with the Use of Non-Steroidal Anti-Inflammatory Drugs.- Kidney Function Impairment: Do Relevant Differences between Non-Steroidal Anti-Inflammatory Drugs Exist?.
