Read more
Cell motility is an important component of many basic physiologic and pathologic processes. Understanding mechanisms of cell motility is therefore essential to the development of new research and clinical approaches in biomedical research. In the early phases of embryogenesis, prepreogrammed morpho genetic movement determines normal development. The migration of the neural crest cells, for example, is responsible for the establishment of almost the entire peripheral nervous system, the proper positioning of the epinephrine-secreting cells in the adrenal gland and the deposition of pigment cells in the skin (Newgreen and Erikson, 1986). Any distur bance or deviation from this complex migration pattern results in serious malformations. The embryonic cells are stimulated to migrate by internal signals as well as by signals from adjacent cells. Various stimulatory and inhibitory mechanisms are likely to operate during this dynamic process. However, once morphogenesis is achieved, most so matic cells tend to remain stationary, and the motile phenotype is dormant. Under certain physiologic and pathologic conditions, however, cells re-express their motile phenotype and migrate. In wound healing and angiogenesis cell migration and proper three-dimensional positioning is critical. Endothelial cell migration following luminal injury is another homeostatic mechanism which helps prevent vascular lesions (Reidy and Silver, 1985; Sholley et aI., 1977; Wong and Gottlieb, 1988). In pathological conditions such as atherosclerosis, smooth muscle cell migration through the internal elastic lamina to the luminal surface may be the initial event leading to the development of the atherosclerotic plaque (Goldberg, 1982).
List of contents
Molecular analysis of amoeboid Chemotaxis: Parallel observations in amoeboid phagocytes and metastatic tumor cells.- Adhesion systems in embryonic epithelial-to-mesenchyme transformations and in cancer invasion and metastasis.- Neutrophil chemotactic factors.- Purification and characterization of scatter factor.- Purification, characterization and mechanism of action of scatter factor from human placenta.- Scatter factor stimulates migration of vascular endothelium and capillary-like tube formation.- The cellular response to factors which induce motility in mammahan cells.- The role of E-cadherin and scatter factor in tumor invasion and cell motility.- Heterogeneity amongst fibroblasts in the production of migration stimulating factor (MSF): Implications for cancer pathogenesis.- Cell motility, a principal requirement for metastasis.- Tumor cell autocrine motility factor receptor.- Interleukin-6 enhances motility of breast carcinoma cells.- Interleukin-6 stimulates motility of vascular endothelium.- Computer automation in measurement and analysis of cell motility in vitro.
