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Zusatztext This is a pioneering work of two doctors who as editors, have undertaken a monumental project, compiling a lot of relatively new knowledge put on paper by a total 50 pioneers in genomic medicine. All the authors and Drs. Kumar and Eng are to be congratulated for this unique, massive contribution to better understanding of disease so that eventually, millions of people can benefit from their work, to lead healthier lives. Informationen zum Autor Professor Dhavendra Kumar, MD, FRCP, FACM, Consultant in Clinical Genetics, Institute of Medical Genetics (Cardiff University), Genomic Policy Unit (University of Glamorgan), University Hospital of Wales, Cardiff University, Cardiff, UKProfessor Charis Eng, MD, PhD, FACP, ACS/Hardis Professor and Chairwoman of the Genomic Medicine Institute and Director of the Center for Personalized Genetic Healthcare, The Cleveland Clinic, Ohio, USA; Professor and Vice Chair of the Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA Klappentext The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. Zusammenfassung The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine. Inhaltsverzeichnis Part I: Principles of Genomic Medicine 1. Genes, genetics and human genomics- Dhavendra Kumar 2. The human genome- structure and organization- Andrew P. Read 3. Human Proteomics- Brian Morrissey, Lisa Staunton, Stephen R Pennington 4. Epigenetics, Epigenomics and Human Disease- Aravind Ramesh, Cihangir Yandim, Theona Natisvili, Marta Mauri, Piu Pik Law, Jackson P.K. Chan, Santiago Uribe Lewis, Richard Festenstein 5. Genes, genome and developmental malformations- Dhavendra Kumar 6. Bioinformatics, Systems Biology and Systems Medicine- Binay Panda and Neeraja M Krishnan 7. Pharmacogenomics - Critical Component of Genomic Medicine- Wolfgang Sadee 8. New Drug Development, Drug Response, and Precision Medicines- Michelle Penny and Duncan McHale 9. Mitochondrial genetics and genomics in clinical medicine- Agnes Rotig and Dhavendra Kumar 10. Genomics Technology in Clinical Diagnostics- Kevin White 11. Microbial Genomics: targeted antimicrobial therapy and genome vaccines- Immaculada Margarit and Rino Rappuoli 12. Nutritional genomics- Zhenglong Gu, Kaixiong Ye and Patrick J. Stover 13. Genomics in Public and Population Health- Anastasia L. Wise and Teri A. Manolio 14. Genetic testing and genomic screening- Angus J. Clarke 15. Biobanking for genomics-based translational medicine- Steven J. Madore 16. Genetics and Genomics Education: The Path from Helix to Health- Reed E. Pyeritz 17. Ethical, Legal and Social Issues in Clinical Genomics- Caroline F. Wright, Anna Middleton and Michael Parker 18. The regulation of human genomics research- Jane Kaye Part II: Genomics in Clinical Practice 19. Genetic and genomic approaches to clinical medicine - Dhavendr...
