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Experts from academia and both the biotechnology and pharmaceutical industries introduce biological, medical and methodological aspects of the emerging field of epigenomics.
List of contents
List of contributors; Foreword; Preface; Part I. Basics of Chromatin Biology and Biochemistry: 1. Introduction to epigenomics; 2. Epigenetics and its historical perspectives; 3. Functional networks of human epigenetic factors; 4. Nucleosome positioning in promoters: significance and open questions; 5. Chemical reporters of protein methylation and acetylation; 6. Long non-coding RNA in epigenetic gene silencing; Part II. Epigenomic Imprinting and Stem Cells: 7. Active DNA demethylation - the enigma starts in the zygote; 8. Histone modifications of lineage specific genes in human embryonic stem cells during in vitro differentiation; 9. Epigenetic stability of human pluripotent stem cells; 10. Impact of CpG methylation in addressing adipose derived stem cell differentiation towards the cardiac phenotype; 11. Regulation of stem cell epigenome by REST; 12. MicroRNAs in embryonic stem cells; 13. Regulation of timing of replication; Part III. Epigenomic Assays and Sequencing Technology: 14. Detection of CpG methylation patterns by affinity capture methods; 15. Genome-wide ChIP-DSL profiling of promoter methylation patterns associated with cancer and stem cell differentiation; 16. Quantitative, high-resolution CpG methylation assays on the pyrosequencing platform; 17. DNA methylation profiling using Illumina BeadArray platform; 18. Advances in capillary electrophoresis-based methods for DNA methylation analysis; 19. Genome-wide methylome analysis based on new HT sequencing technology; 20. 3-D quantitative DNA methylation imaging for chromatin texture analysis in pharmacoepigenomics and toxicoepigenomics; Part IV. Epigenomics in Disease Biology: 21. Cancer classification by genome-wide and quantitative DNA methylation analyses; 22. Promoter CpG island methylation in colorectal cancer: biology and clinical applications; 23. The epigenetic profile of bladder cancer; 24. Genome-scale DNA methylation analyses of cancer in children; 25. The epigenetics of facioscapulohumeral muscular dystrophy; 26. Modulating histone acetylation with inhibitors and activators; Part V. Epigenomics in Neurodegenerative Diseases: 27. Study design considerations in epigenetic studies of neuropsychiatric disease; 28. Epigenetic regulation in human neurodevelopmental disorders including autism, Rett syndrome and epilepsy; 29. The neurobiology of chromatin-associated mechanisms in the context of psychosis and mood spectrum disorders; 30. Genome-wide DNA methylation analysis in patients with familial ATR-X mental retardation syndrome; 31. Kinases and phosphatases in the epigenetic regulation of cognitive functions; Part VI. Epigenetic Variation, Polymorphism and Epidemiological Perspectives: 32. Epigenetic effects of childhood abuse on the human brain; 33. X-linked expressed SNPs and dosage compensation; 34. Epigenomic diversity of colorectal cancer; 35. Epigenetic epidemiology: transgenerational responses to the environment; Index.
About the author
Krishnarao Appasani is the Founder and Chief Executive Officer of GeneExpression Systems, a conference producing organization focusing on Biomedical and Physical Sciences. He is editor of MicroRNAs: From Basic Science to Disease Biology (2007) and RNA Interference: From Basic Science to Drug Development (2005), also published by Cambridge University Press.
Summary
Leading experts from academia and both the biotechnology and pharmaceutical industries introduce the emerging field of epigenomics, covering a wide range of topics and methods such as basic chromatin biology, imprinting at genome-wide level, and the role of epigenomics in disease biology and epidemiology.
