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Heterocyclic compounds have played an important role in the evolution of life, as dyes, drugs and are also used in many commercially important species. Pyrroles and their derivatives exhibit different important biological activities like antibacterial, antioxidant, cytotoxic, insecticidal, anti-inflammatory, anticoagulant, antiallergic, antiarhythmic, hypotensive and anticonvulsant etc. Benzylideneacetophenones play an ecological role in nature, in relation to plant colour. These brightly yellow coloured compounds are found in many plant organs, but most conspicuously in flowers. Benzylideneacetophenones contain reactive keto ethylenic (enone) group. The presence of enone fraction in the benzylideneacetophenones molecule confers antibiotic activity (bacteriostatics /bactericidal) upon it. This property is enhanced when substitution is made at the -(nitro and bromo) and beta-(bromo and hydroxylic) position. Some substituted benzylideneacetophenones and their derivatives, including some of their heterocyclic analogues, have been reported to possess some interesting biological properties, which are detrimental to the growth of microbes, tubercle bacilli, malarial parasites, acrus, Schis
About the author
Dr. Meghasham Narayanrao Narule Diretor do Departamento de Química, Faculdade VVACS. Samudrapur Guia de Doutoramento, Universidade RTM de Nagpur, Nagpur Guia de Doutoramento, Universidade Gondwana, Gadchiroli Doutoramento (Química Orgânica), Doutoramento (Administração de Empresas), Mestrado (Química Orgânica), MBA (RH).
