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The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway.
Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.
List of contents
Production and action of type I interferons in host defense.- Induction and consequences of the type I IFN response to Listeria monocytogenes.- Innate immune and type I IFN responses during Legionella pneumophila infection.- Type I interferons in immune defense against streptococci.- Activation of type I IFN signaling by Staphylococcus aureus.- Contribution of interferon signaling to host defense against Pseudomonas aeruginosa.- The detrimental role of type I interferon signaling during infection with Salmonella typhimurium.- Yersinia activation of type I interferon.- Induction and Function of Type I IFNs During Chlamydial Infection.- Regulation of Host Response to Mycobacteria by Type I Interferons.
Summary
The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway.
Bacterial Activation of Type I Interferonsreviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.
