Genetics of the Mouse

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.

The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.

In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

List of contents

Origins of the Laboratory Mouse.- Basic Concepts of Reproductive Biology And Genetics.- Cytogenetics.- Gene Mapping.- The Mouse Genome.- Epigenetic Control of Genome Expression.- Mutations and Experimental Mutagenesis.- Transgenesis and Transgenic Animals.- The Different Categories of Genetically Standardized Populations of Laboratory Mice.- Quantitative Traits and Quantitative Genetics.

Product details

• Authors: Fernand Benavides, Fernando Benavides, Jean Loui Guénet, Jean Louis Guénet, Xavier Montagutelli, J Panthier, Jean-Jacques Panthier
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 27.06.2014
• EAN: 9783662442869
• ISBN: 978-3-662-44286-9
• No. of pages: 408
• Dimensions: 162 mm x 237 mm x 30 mm
• Weight: 807 g
• Illustrations: XVII, 408 p. 106 illus., 44 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; B, biotechnology, Zoology & animal sciences, Genetic Engineering, Biomedical and Life Sciences, Medical Genetics, Zoology, Genetics (non-medical), Animal genetics, Agricultural Genetics, Animal Genetics and Genomics, Gene Expression, Transgenic organisms, Transgenics, Animal models in research, Animal Models, Experimental Organisms