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Informationen zum Autor Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer. Klappentext This two-volume set provides a full account of the entire sequence of drug development, from conceptualizing the drug, creating a library of candidates, and conducting clinical trials, to optimizing the synthetic route, marketing the drug, and developing delivery methods. Comprehensive in scope, the set bridges the gap between medicinal and process chemistry.Discussion includes the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Case studies examine the discovery of erythromycin analogs (antibiotics), Tagamet, and Ultiva (remifentanil). Full chapters are devoted to combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics. Industrial chemists, biologists, biochemists, and business people in the pharmaceutical industry will all benefit from this authoritative reference.The first volume of this set thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.The second volume describes optimizing the synthetic route; manufacturing, outsourcing, and marketing the drug, including coloring; and developing delivery methods. Zusammenfassung This innovative two-volume set offers a unique, integrated presentation of the full spectrum of operations involved in drug discovery and development. The set covers the strategies, tactics, milestones, and benchmarks throughout the entire sequence of operations, from discovering a drug to prescribing it. Inhaltsverzeichnis Bioactive Molecules in Medicinal Plants: A Perspective on their Therapeutic Action / S C Taneja, G N Qazi Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools / Steven V Ley, Ian R Baxendale, Deborah A Longbottom, Rebecca M Myers Insulin Sensitizers: Emerging Therapeutics / Braj B Lohray, Vidya B Lohray Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals / Raymond McCague, Ian C Lennon Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons / J S Yadav, S Chandrasekhar Carbohydrates: From Chirons to Mimics / G V M Sharma, Palakodety Radha Krishna Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients / Yatendra Kumar, B Vijayaraghavan Importance of Polymorphs and Salts in the Pharmaceutical Industry / Bipin Pandey, Vidya B Lohray, Braj B Lohray Role of Outsourcing in Drug Manufacture / Peter Pollak Regulation-Driven Process Chemistry / Shrikant V Kulkarni Chemical Process Scale-Up Tools: Mixing Calculations, Statistical Design of Experiments, and Automated Laboratory Reactors / Andrei A Zlota Library Quality Metrics / Richard L Wife, Johan Tijhuis Tying a GABA from Copenhagen to Chicago: The Chemistry of Tiagabine / Mukund S Chorghade, Mahendra N Deshpande, Richard J Pariza Building Contract Research Businesses Based on Integration of Basic and Applied Research / Mukund S Chorghade, Mukund K Gurjar, C V Ramana, Sreenivas Punna Principles and Practice of Clinical Drug Development / Colin Scott Index. Volume 1. Drug discovery [chapters 1-16] Volume 2. Drug development [chapters 17-31]. From patent to prescription : paving the ...
