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Informationen zum Autor Dr Paul M Dewick , Formerly of the School of Pharmaceutical Sciences, University of Nottingham, UK (now retired). Paul Dewick is the author of Medicinal Natural Products: A Biosynthetic Approach , and Essentials of Organic Chemistry: For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry (Wiley, 2006). Klappentext Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine.There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions:* a comprehensive treatment of plant, microbial, and animal natural products in one volume* extensive use of chemical schemes with annotated mechanistic explanations* cross-referencing to emphasize links and similarities* boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of actionMedicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry. Zusammenfassung Medicinal Natural Products: A Biosynthetic Approach, Third Edition , provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. Inhaltsverzeichnis 1 About this book, and how to use it 1 The subject 1 The aim 1 The approach 2 The topics 2 The figures 2 Further reading 3 What to study 3 What to learn 3 Nomenclature 3 Conventions regarding acids, bases, and ions 4 Some common abbreviations 4 Further reading 5 2 Secondary metabolism: the building blocks and construction mechanisms 7 Primary and secondary metabolism 7 The building blocks 8 The construction mechanisms 11 Alkylation reactions: nucleophilic substitution 12 Alkylation reactions: electrophilic addition 12 Wagner-Meerwein rearrangements 15 Aldol and Claisen reactions 15 Imine formation and the Mannich reaction 18 Amino acids and transamination 20 Decarboxylation reactions 22 Oxidation and reduction reactions 24 Dehydrogenases 24 Oxidases 26 Monooxygenases 26 Dioxygenases 26 Amine oxidases 27 Baeyer-Villiger monooxygenases 27 Phenolic oxidative coupling 28 Halogenation reactions 28 Glycosylation reactions 31 Elucidating biosynthetic pathways 34 Further reading 38 3 The acetate pathway: fatty acids and polyketides 39 Fatty acid synthase: saturated fatty acids 39 Unsaturated fatty acids 44 Uncommon fatty acids 53 Prostaglandins 58 Thromboxanes 64 Leukotrienes 64 Polyketide synthases: generalities 66 Polyketide synthases: macrolides 68 Polyketide synthases: linear polyketides and polyethers 90 Diels-Alder cyclizations 96 Polyketide synthases: aromatics 96 Cyclizations 99 Post-polyketide synthase modifications 103 Starter groups 116 Further read...
