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Informationen zum Autor Teresa? K. Attwood, Professor of Bioinformatics, University of Manchester, UK. Stephen R. Pettifer, Lecturer of Computer Science,?University of Manchester, UK. Klappentext This innovative book provides a completely fresh exploration of bioinformatics, investigating its complex interrelationship with biology and computer science. It approaches bioinformatics from a unique perspective, highlighting interdisciplinary gaps that often trap the unwary.The book considers how the need for biological databases drove the evolution of bioinformatics; it reviews bioinformatics basics (including database formats, data-types and current analysis methods), and examines key topics in computer science (including data-structures, identifiers and algorithms), reflecting on their use and abuse in bioinformatics.Bringing these disciplines together, this book is an essential read for those who wish to better understand the challenges for bioinformatics at the interface of biology and computer science, and how to bridge the gaps. It will be an invaluable resource for advanced undergraduate and postgraduate students, and for lecturers, researchers and professionals with an interest in this fascinating, fast-moving discipline and the knotty problems that surround it. Zusammenfassung This innovative book provides a completely fresh exploration of bioinformatics! investigating its complex interrelationship with biology and computer science. It approaches bioinformatics from a unique perspective! highlighting interdisciplinary gaps that often trap the unwary.The book considers how the need for biological databases drove the evolution of bioinformatics; it reviews bioinformatics basics (including database formats! data-types and current analysis methods)! and examines key topics in computer science (including data-structures! identifiers and algorithms)! reflecting on their use and abuse in bioinformatics.Bringing these disciplines together! this book is an essential read for those who wish to better understand the challenges for bioinformatics at the interface of biology and computer science! and how to bridge the gaps. It will be an invaluable resource for advanced undergraduate and postgraduate students! and for lecturers! researchers and professionals with an interest in this fascinating! fast-moving discipline and the knotty problems that surround it. Inhaltsverzeichnis Preface x Acknowledgements xvii About the companion website xviii PART 1 1 Introduction 3 1.1 Overview 3 1.2 Bioinformatics 3 1.2.1 What is bioinformatics? 3 1.2.2 The provenance of bioinformatics 4 1.2.3 The seeds of bioinformatics 5 1.3 Computer Science 7 1.3.1 Origins of computer science 7 1.3.2 Computer science meets bioinformatics 9 1.4 What did we want to do with bioinformatics? 10 1.5 Summary 12 1.6 References 13 1.7 Quiz 14 1.8 Problems 16 2 The biological context 17 2.1 Overview 17 2.2 Biological data?]types and concepts 17 2.2.1 Diversity of biological data?]types 17 2.2.2 The central dogma 18 2.2.3 Fundamental building?]blocks and alphabets 19 2.2.4 The protein structure hierarchy 29 2.2.5 RNA processing in prokaryotes and eukaryotes 30 2.2.6 The genetic code 33 2.2.7 Conceptual translation and gene finding 35 2.3 Access to whole genomes 42 2.4 Summary 43 2.5 References 43 2.6 Quiz 46 2.7 Problems 47 3 Biological databases 49 3.1 Overview 49 3.2 What kinds of database are there? 49 3.3 The Protein Data Bank (PDB) 50 3.4 The EMBL nucleotide sequence data library 56 3.5 GenBank 58 3.6 The PIR?]PSD 61 3.7 Swiss?]Prot 62 3.8 PROSITE 64 3.9 TrEMBL 69 3.10 InterPro 71
