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Informationen zum Autor Dr Gareth Thomas , The University of Portsmouth, UK. Klappentext Medicinal Chemistry, Second Edition provides a comprehensive, balanced introduction to this evolving, multi-disciplinary subject. The book carefully explains fundamental principles, assuming little in the way of prior knowledge. It opens with a broad overview of medicinal chemistry followed by chapters that cover the principal methods used in drug design and the isolation of drugs from natural sources. Subsequent chapters discuss more specialised aspects of medicinal chemistry and outline drug and analogue synthesis, development and production. Each chapter contains self-assessment questions, numerous examples and a wide variety of applications.Building on the success of the first edition, the book has been completely redesigned to create a clearer, more logical presentation of the material. The text has been extensively revised and updated and includes two new chapters on drugs from natural sources, and drug development and production.* Provides a comprehensive, accessible, clearly written introduction to medicinal chemistry* Assumes little prior knowledge of biology and a familiarity with chemistry at first year level* Includes numerous examples of drugs and drug action.* Questions are provided at the end of each chapter with answers at the end of the book* Completely revised and updated to include many of the latest drugs and treatmentsMedicinal Chemistry, Second Edition will prove invaluable to students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology whose course includes medicinal chemistry units. Zusammenfassung Medicinal Chemistry, Second Edition provides a comprehensive, balanced introduction to this evolving, multi-disciplinary subject. The book carefully explains fundamental principles, assuming little in the way of prior knowledge. It opens with a broad overview of medicinal chemistry followed by chapters that cover the principal methods used in drug design and the isolation of drugs from natural sources. Subsequent chapters discuss more specialised aspects of medicinal chemistry and outline drug and analogue synthesis, development and production. Each chapter contains self-assessment questions, numerous examples and a wide variety of applications.Building on the success of the first edition, the book has been completely redesigned to create a clearer, more logical presentation of the material. The text has been extensively revised and updated and includes two new chapters on drugs from natural sources, and drug development and production.* Provides a comprehensive, accessible, clearly written introduction to medicinal chemistry* Assumes little prior knowledge of biology and a familiarity with chemistry at first year level* Includes numerous examples of drugs and drug action.* Questions are provided at the end of each chapter with answers at the end of the book* Completely revised and updated to include many of the latest drugs and treatmentsMedicinal Chemistry, Second Edition will prove invaluable to students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology whose course includes medicinal chemistry units. Inhaltsverzeichnis Preface to the First Edition xv Preface to the Second Edition xvii Acknowledgements xix Abbreviations xxi 1 An introduction to drugs, their action and discovery 1 1.1 Introduction 1 1.2 What are drugs and why do we need new ones? 1 1.3 Drug discovery and design: a historical outline 3 1.3.1 The general stages in modern-day drug discovery and design 7 1.4 Leads and analogues: some desirable properties 9 1.4.1 Bioavailability 9 1.4.2 Solubility 10 1.4.3 Structure 10 1.4.4 Stability 11 1.5 Sources of leads and drugs 14 1.5.1 Ethnopharmaceutical sources 15 1.5.2...
