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Informationen zum Autor Paul Cumming is a Visiting Professor in the Department of Nuclear Medicine at Ludwig-Maximillian University in Germany. He currently serves on the editorial boards of the journals Synapse, Journal of Cerebral Blood Flow and Metabolism, and NeuroImage. Klappentext An illustrated biography of the dopamine molecule, with each chapter presenting a specific stage in the biochemical pathway for dopamine. Zusammenfassung During the past 25 years! new methods for molecular imaging have illuminated aspects of the life of dopamine in health and illness. Presented as an illustrated biography! covering specific stages in the biochemical pathway! this book is a compilation of all that has been learned about dopamine through molecular imaging. Inhaltsverzeichnis 1. The life history of dopamine; 2. Enzymology of tyrosine hydroxylase; 3. The assay of tyrosine hydroxylase; 4. Enzymology of aromatic amino acid decarboxylase (AAADC); 5. PET studies of DOPA utilization; 6. Conjugation and sulfonation of dopamine and its metabolites; 7. Dopamine synthesis and metabolism rates; 8. MAO activity in brain; 9. Vesicular storage of dopamine; 10. Dopamine release: from vesicles to behavior; 11. The plasma membrane dopamine transporter (DAT); 12. Dopamine receptors; 13. Imaging dopamine D1 receptors; 14. Imaging dopamine D2 receptors; 15. Factors influencing D2 binding in living brain; 16. The absolute abundance of dopamine receptors in brain; 17. Perspectives.
