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Informationen zum Autor Norbert W. Lutz is Research Professor at the School of Medicine at the University of Aix-Marseille, France. He has previously held positions at the Johns Hopkins University School of Medicine, the German Cancer Research Center, the University of Arizona Cancer Center and other internationally renowned research institutions. His research is primarily focused on the analysis of metabolic processes in cancer and in neurological diseases. His papers have appeared in Analytical Chemistry, Annals of Neurology, PLoS ONE, International Journal of Cancer, AIDS, Metabolomics, NMR in Biomedicine and other journals. Jonathan V. Sweedler is the James R. Eiszner Family Professor of Chemistry and the Director of the School of Chemical Sciences at the University of Illinois at Urbana-Champaign, USA. His major research efforts involve developing new approaches for small-volume peptidomics and metabolomics and the application of these technologies to study novel neuro-chemical pathways. Professor Sweedler has published more than 350 manuscripts, book chapters and reviews and has presented 350 invited lectures relate to research in these areas. He is Editor-in-Chief of Analytical Chemistry. Ron Wevers is head of the laboratory of Genetic Endocrine and Metabolic Diseases of the Radboud University Nijmegen Medical Centre in the Netherlands. He has a chair in Clinical Chemistry of Inborn Errors of Metabolism. Professor Wevers is also a member of the Dutch Health Council. He has co-authored more than 300 peer-reviewed papers and many book chapters and wrote a handbook on body fluid NMR spectroscopy in patients with inborn errors of metabolism. Klappentext Methodologies for Metabolomics provides comprehensive descriptions of the newest methodological strategies and techniques in metabolomic research. Zusammenfassung Methodologies for Metabolomics provides comprehensive descriptions of the newest strategies in metabolomic research. While a broad range of methodologies are presented! so too are applications including in vivo metabolomics in humans and animals as well as in vitro analysis of tissue samples! cultured cells and biofluids. Inhaltsverzeichnis List of contributors; Part I. Basic Methodological Strategies in Metabolomic Research: 1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy; 2. Methodological requirements for lipidomics research; 3. Biological methods for metabolic research; Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics: 4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling; 5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification; 6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization; 7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data; 8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy; 9. Metabolomics using ion mobility mass spectrometry; 10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications; Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics: 11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry; 12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis; 13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome; 14. Nuclear magnetic resonance-based saliva metabolomics; 15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid; 16. Nuclear magnetic resonance analysis and genetic metabolic disease; 17. Lipid profiling in health and disea...
