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Zusatztext This book organizes and communicates an amazing amount of biophysics using bacterial chemotaxis as an organizing theme. Endres, a leading researcher in cell signaling, writes in an accessible way and coherently covers a vast range of topics - e.g. diffusion, noise, allostery, membrane energetics, information theory, optimization - with crossover appeal to biologists, physicists, and engineers. This work is ideal for senior undergraduates or graduate students with an interest in the exploding field of quantitative biology. Informationen zum Autor At Imperial College Robert Endres heads the Biological Physics Group. Recently he won the prestigious ERC Strating Grant award. Before moving to the United Kingdom, Robert was a postdoc with Prof. Ned Wingreen in the Molecular Biology Department at Princeton University, where his main research accomplishments were the understanding of the remarkable signalling properties of bacterial chemotaxis and the atomistic prediction of protein-DNA binding sites. Klappentext The book addresses how biological cells work, and specifically achieve their remarkable sensing and signaling properties using insights from physics and engineering. The book aims to teach concepts, omitting many of the technical details, and hence should attract a broad readership. Zusammenfassung The book addresses how biological cells work, and specifically achieve their remarkable sensing and signaling properties using insights from physics and engineering. The book aims to teach concepts, omitting many of the technical details, and hence should attract a broad readership. Inhaltsverzeichnis 1: Preface 2: Introduction 3: Physical concepts 4: Mathematical tools 5: Chemotaxis in bacterium Escherichia coli 6: Signal amplification and integration 7: Robust precise adaptation 8: Polar receptor localization and clustering 9: Accuracy of sensing 10: Motor impulse response 11: Optimization of pathway 12: 'Seeing' like a bacterium 13: Beyond E. coli chemotaxis ...
