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Informationen zum Autor Jeffrey L. Noebels MD! PhDDr. Noebels is Cullen Trust for Health Care Endowed Chair Professor of Neurology! Neuroscience! and Molecular and Human Genetics at Baylor College of Medicine. He is also Vice Chair for Research and Director of the Blue Bird Circle Developmental Neurogenetics Laboratory in the Department of Neurology. The focus of his research is on genetic and cellular mechanisms of neuronal synchronization disorders in the developing brain. Massimo Avoli! MDDr. Avoli is Professor in the Department of Neurology and Neurosurgery! and in the Department of Physiology at McGill University. He is also Professor of Human Physiology at Sapienza University of Rome. His research focuses on the cellular and pharmacological mechanisms underlying excitability and epileptiform synchronization! epileptogenesis! and mental retardation syndromes.Michael A. Rogawski! MD! PhDDr. Rogawski is professor and chair of the Department of Neurology at the University of California! Davis School of Medicine. He previously served as chief of the Epilepsy Research Section at the National Institute of Neurological Disorders and Stroke. His research is on the cellular mechanisms of action of antiepileptic drugs and new epilepsy treatment approaches.Dr. Olsen is Distinguished Professor of Neuroscience! Pharmacology! and Anesthesiology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA)! in the Department of Molecular & Medical Pharmacology. The focus of his research is the structure and function of GABA-A receptors in the brain including their involvement in epilepsy and alcoholism.Antonio V. Delgado-Escueta! MDDr. Delgado-Escueta is Professor in Residence in Neurology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA). He is also director of the Epilepsy Center of Excellence at the VA Greater Los Angeles Healthcare System in West Los Angeles. The focus of his research is isolating human epilepsy genes and defining their disease mechanisms. Klappentext Jasper's Basic Mechanisms! Fourth Edition! is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment. The book represents an encyclopedic compendium neurobiological mechanisms of seizures! epileptogenesis! epilepsy genetics and comordidconditions. Of practical importance to the clinician! and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches! ranging from novel antiepileptic drug targets to cell and gene therapies. Zusammenfassung H.H. Jasper! A.A. Ward! A. Pope and H.H. Merritt! chair of the Public Health Service Advisory Committee on the Epilepsies! National Institutes of Health! published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then! basic and clinical researchers in epilepsy have gathered together every decadeand a half with these goals in mind - assessing where epilepsy research has been! what it has accomplished! and where it should go. In 1999! the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the pastfour decades! this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters! the book considers the role of interactions between neurons! synapses! and glia in the initiation! spread and arrest of seizures. It examines mechanisms of excitability! synchronization! seizure susceptibility! and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and unde...
