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Klappentext The field of immunology has progressed so much since the first edition of this book was published seven years ago! that this fully updated second edition appears as a major new work. Its wide scope! depth of coverage! and eminence of authorship make it unique in the field. Like other volumes in the Frontiers in Molecular Biology series! this book presents an up-to-date picture of current research topics in a key area. The contributors to this book have been carefully chosen to reflect the main thrusts of research efforts across a broad range within the rapidly developing field of immunology. Subjects covered include immunoglobulin gene rearrangement! the MHC antigens! B-cell activation! and the complement system. The book is well-illustrated! and there are over 1900 references cited. Zusammenfassung The book is a collection of up-to-date reviews by major researchers in the field of the fast-moving area of modern immunology. Its wide scope, depth of coverage, well-illustrated text, and the eminence of the authorship make it unique in its field. Over 1900 literature reference are cited. So much has happened in immunology since publication of the first edition of this popular book seven years ago that the second edition is a major new work. The chapters on mechanism and control of immunoglobulin genes by Fred Alt and his colleagues, T-cell antigen receptor genes by Mark Davis and Yeuh-hsui Chien, T lymphocyte signal transduction by Cox Terhorst et al, and the complement system by Ken Reid are all major updates and extensions of their first edition contributions. In addition, the second edition contains new chapters by David Jewell and Ian Wilson on the structure and function on MHC class I and class II antigens, by John Monaco on molecular mechanisms of antigen processing. By Gerry Klaus on B cell activation, and by Martine Verhoeyen and John Windust in recent advances by antibody engineering. Inhaltsverzeichnis 1.: Rusty Lansford, Ami Okada, Jianzhu Chen, Eugene M. Oltz, T. Keith Blackwell, Frederick W. Alt, and Gary Rathbun: Mechanism and control of immunoglobulin gene rearrangement 2.: Mark M. Davis and Yueh-hsui Chien: T cell antigen recepotor genes 3.: Cox Terhorst, Mark Exley, Frank Staal and Hergen Spits: T lymphocyte signal transduction 4.: David Jewell and Ian A. Wilson: Structure and function of MHC class I and class II antigens 5.: John J. Monaco: Molecular mechanisms of antigen processing 6.: Gerry G.B. Klaus: B cell activation 7.: Martine E. Verhoeyen and John H.C. Windust: Advances in antibody engineering 8.: Kenneth B.M. Reid: The complement system ...
