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Zusatztext '...It is the most comprehensive volume on microsatellities and has contributions from many excellent researchers' TREE Informationen zum Autor David B Goldstein, Department of Zoology, University of Oxford, South Parks ROad, Oxford OX1 3PS david.goldstein@zoo.ox.ac.uk Christian Schlötterer, Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Vienna, Austria christian.schloetterer@vu-wien.ac.at Klappentext Microsatellites are short stretches of repeated DNA that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for numerous applications! including genetic mapping and studies of evolutionary connections between species and populations. This book details the molecular processes which give rise to microsatellite DNA and then describes the wide range of applications in medical genetics! forensics! the study of human evolution! and conservation genetics. Drawing from an international group of researchers! the book presents the theoretical background and the hands-on details for many of the popular analytic methods using microsatellites! including methods for estimating coalescent times! population divergences! and migration. Zusammenfassung Microsatellites are short stretches of repeated DNA that show exceptional variability in humans and other species. This book details the molecular processes that have given rise to microsatellite DNA. It describes the various ways in which the potential of microsatellites is being harnessed in medical genetics, evolutionary biology, and ecology. 1. Microsatellites and other simple sequences; 2. Functional roles of microsatellites and minisatellites; 3. Microsatellites and mutation processes in tandemly repetitive DNA; 4. Mechanistic basis for microsatellite instability; 5. Microsatellite evolution : inferences from population data; 6. A comparative approach to the study of microsatellite evolution; 7. Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations; 8. Mutation and migration in models of microsatellite evolution; 9. The coalescent and microsatellite variability; 10. Estimating the age of mutations using variation of linked markers; 11. Statistics of microsatellite loci : Estimation of mutation rate and pattern of population expansion; 12. Using microsatellites to measure the fitness consequences of inbreeding and outbreeding; 13. Microsatellites in conservation genetics; 14. Microsatellites and the reconstruction of the history of human populations; 15. Forensic applications of microsatellite markers; 16. Tracking linkage disequilibrium in advanced population with microsatellite loci; 17. Microsatellite markers in complex disease : mapping disease - associated regions within the human MHC; 18. Microsatellites : a neutral marker to infer selective sweeps; 19. Y chromosome microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia; 20. MS analysis of human tumours...
