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Zusatztext It is worth its price Klappentext During the last ten years, remarkable progress has occurred in the study of molecular evolution. Among the most important factors that are responsible for this progress are the development of new statistical methods and advances in computational technology. In particular, phylogenetic analysisof DNA or protein sequences has become a powerful tool for studying molecular evolution. Along with this developing technology, the application of the new statistical and computational methods has become more complicated and there is no comprehensive volume that treats these methods in depth.Molecular Evolution and Phylogenetics fills this gap and present various statistical methods that are easily accessible to general biologists as well as biochemists, bioinformatists and graduate students. The text covers measurement of sequence divergence, construction of phylogenetic trees, statistical tests for detection of positive Darwinian selection, inference of ancestral amino acid sequences, construction of linearized trees, and analysis of allele frequency data. Emphasis is given to practical methods of data analysis, and methods can be learned by working through numericalexamples using the computer program MEGA2 that is provided. Zusammenfassung Presents the statistical methods that are useful in the study of molecular evolution and illustrates how to use them in actual data analysis. This book for graduate students and researchers helps the investigators to incorporate refined statistical analysis of large-scale data in their own work. Inhaltsverzeichnis 1: Molecular basis of evolution 2: Evolutionary changes of amino acid sequences 3: Evolutionary changes of DNA sequences 4: Synonymous and Nonsynonymous nucleotide subsitutions 5: Phylogenetic Trees 6: Phylogenetic inference: Distance methods 7: Phylogenetic inference: Maximum parsimony methods 8: Phylogenetic inference: Maximum likelihood methods 9: Accuracies and statistical tests of phylogenetic trees 10: Molecular clocks and linearized trees 11: Ancestral Nucleotide and amino acid sequences 12: Genetic polymorphism and evolution 13: Population trees from genetic markers 14: Perspectives Appendices A. Mathematical symbols and notations B. Geological timescale C. Geological events in the Cenozoic and Mesozoic eras D. Evolution of organisms based on the fossil record ...
