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Zusatztext Overall this is an extremely well-written book, with a clear and concise narrative that is immensely readable. I would highly recommend it to anyone with an interest in the history of bacteriology, microbial genetics or antibiotics. Klappentext This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections! as well as anti-cancer! anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomyceteswere discovered in the latter part of the nineteenth century! but remained a Cinderella group until! in the 1940s! they shot to prominence with the discovery of streptomycin! the first effective treatment for tuberculosis and only the second antibiotic! after penicillin! to become a medical marvel.There followed a massive effort over several decades to find further treatments for infectious diseases and cancer! tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in thecontext of the rise of microbial genetics in the mid-20th century! leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and developmentto life in the soil! including antibiotic production! is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel! hybrid! antibiotics! and a topical description of techniques to learn the roles of the thousands of genes in a genomesequence! throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy! the first actinomycetes to be discovered! and how methodology! in part derived fromthe study of the streptomycetes! is being applied to understand and control these still deadly pathogens. Zusammenfassung This book highlights the lives of a group of soil microbes that make most of the antibiotics used in medicine today. Written by an insider, it describes how genetics tells us how these microscopic chemists compete in the soil and how their genes can be rearranged to make new antibiotics to fight re-emerging diseases....
