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Klappentext This timely book assesses all aspects of treatment-resistant depression and will be invaluable to professionals. Zusammenfassung A substantial proportion of patients suffering from depression fail to respond to antidepressants! yet there is little published information available to clinicians for diagnosis and management of treatment-resistant depression. This timely book gives a critical assessment of all aspects of treatment and will be invaluable to clinicians and professionals. Inhaltsverzeichnis List of contributors; Preface; Part I. The Clinical Problem: 1. The characterization and definition of treatment-resistant mood disorders Daniel Souery, Olivier Lipp, Isabelle Massat and Julien Mendlewicz; 2. Overview of treatment-resistant depression and its management John P. O'Reardon and Jay D. Amsterdam; Part II. Biological Basis: 3. Psychoneuroendocrine aspects of treatment-resistant mood disorders Owen M. Wolkowitz and Victor I. Reus; 4. Estrogen and depressive illness in women Barbara B. Sherwin; 5. Sleep abnormalities in treatment-resistant mood disorders Martin P. Szuba, Antonio T. Fernando and Geralyn Groh-Szuba; 6. Structural and functional brain imaging in treatment-resistant depression Terence A. Ketter, Christopher J. Bench, Mark S. George, Tim A. Kimbrell and Robert M. Post; 7. Immunologic factors in treatment-resistant depression Anna Sluzewska, Janusz Rybakowski, Mady Hornig and Jay D. Amsterdam; Part III. Treatment Approaches: 8. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in treatment-resistant depression William Boyer and Richard Bunt; 9. Conventional and second generation monoamine oxidase inhibitors in treatment-resistant depression David Bakish and Cynthia L. Hooper; 10. Drug combination strategies Lawrence H. Price, Linda L. Carpenter and Steven A. Rasmussen; 11. Electroconvulsive therapy in medication-resistant depression Max Fink; 12. Thyroid augmentation Russell T. Joffe; 13. Cognitive therapy and psychosocial interventions in chronic and treatment-resistant mood disorders Jan Scott and Robert J. DeRubeis; Part IV. Special Patient Populations: 14. Chronic and refractory mood disorders in childhood and adolescence Adelita Segovia, Kelly N. Botteron and Barbara Geller; 15. Treatment-resistant depression in the elderly Paul A. Newhouse and Jaskaran Singh; 16. Management of treatment-resistant depression during pregnancy and the postpartum period Zachary N. Stowe, Pamela McCreary, Amy Hostetter, Claudia Baugh and Alexis Llewellyn; 17. Preliminary algorithms for treatment-resistant bipolar depression Robert M. Post, Mark A. Frye, Kirk D. Denicoff, Andrew M. Speer, Susan R. B. Weiss and Gabriele S. Leverich; 18. Medical disorders and treatment-resistant depression John P. O'Reardon and Jay D. Amsterdam; 19. Psychiatric comorbidity in treatment-resistant depression Jonathan E. Alpert and Isabelle T. Lagomasino; 20. Suicide in treatment-refractory depression Jan Fawcett and Stanley G. Harris Sr; Part V. Economic and Ethical Issues: 21. The economic impact of treatment non-response in major depressive disorders Jeffrey S. McCombs, Glen L. Stimmel, Rita L. Hui and T. Jeffrey White; 22. Ethical issues in research and treatment of patients with mood disorders Paul Root Wolpe and Arthur Caplan; Index....