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Informationen zum Autor Pavel Pevzner is Ronald R. Taylor Professor of Computer Science and Director of the Bioinformatics and Systems Biology Program at the University of California, San Diego. He was named a Howard Hughes Medical Institute Professor in 2006. Ron Shamir is the Raymond and Beverly Sackler Professor of Bioinformatics and Head of the Edmond J. Safra Bioinformatics Program at Tel Aviv University. He founded the joint Life Sciences/Computer Science undergraduate degree program in Bioinformatics at Tel Aviv University. Klappentext A team of renowned bioinformaticians take innovative approaches to lead biology students from first principles towards computational thinking. Zusammenfassung A team of renowned bioinformaticians take fresh approaches to lead biology students from first principles towards computational thinking. Intuitive explanations promote deep understanding! using little mathematical formalism. Covering essential bioinformatic topics in a concise textbook! the authors prepare students to meet the computational challenges of their life science careers. Inhaltsverzeichnis Preface; Acknowledgements; Introduction Pavel Pevzner and Ron Shamir; Part I. Genomes: 1. Identifying the genetic basis of disease Vineet Bafna; 2. Pattern identification in a haplotype block Kun-Mao Chao; 3. Genome reconstruction: a puzzle with a billion pieces Phillip Compeau and Pavel Pevzner; 4. Dynamic programming: one algorithmic key for many biological locks Mikhail Gelfand; 5. Measuring evidence: who's your daddy? Christopher Lee; Part II. Gene Transcription and Regulation: 6. How do replication and transcription change genomes? Andrei Grigoriev; 7. Modeling regulatory motifs Sridhar Hannenhalli; 8. How does influenza virus jump from animals to humans? Haixu Tang; Part III. Evolution: 9. Genome rearrangements Steffen Heber and Brian Howard; 10. The crisis of the tree of life concept and the search for order in the phylogenetic forest Eugene Koonin, Pere Puigbò and Yuri Wolf; 11. Reconstructing the history of large-scale genomic changes: biological questions and computational challenges Jian Ma; Part IV. Phylogeny: 12. Figs, wasps, gophers, and lice: a computational exploration of coevolution Ran Libeskind-Hadas; 13. Big cat phylogenies, consensus trees, and computational thinking Seung-Jil Sun and Tiffani Williams; 14. Algorithm design for large-scale phylogeny Tandy Warnow; Part V. Regulatory Networks: 15. Biological networks uncover evolution, disease, and gene functions Nataša Pržulj; 16. Regulatory network inference Russell Schwartz; Index....
