High-Density Lipoproteins - Structure, Metabolism, Function and Therapeutics

Informationen zum Autor Anatol Kontush , BSc (Hons), PhD, is Research Director at the Dyslipidemia and Atherosclerosis Research Unit of the National Institute of Health and Medical Research (INSERM) at the Pitié-Salpêtrière Hospital, Paris, France. An award-winning scientist, Dr. Kontush has authored more than 100 original papers and book chapters. M. John Chapman , BSc, PhD, DSc, FESC, is President of the European Atherosclerosis Society and Director of the Dyslipidemia and Atherosclerosis Research Unit of the National Institute of Health and Medical Research (INSERM) at the Pitié-Salpêtrière Hospital in Paris, France, affiliated with the medical faculty of the Pierre and Marie Curie University, Paris. He has authored more than 400 articles and book chapters. Klappentext A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapiesWith high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL.Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles.Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future. Zusammenfassung High-density lipoprotein, HDL, is one of the hottest topics in lipid research and cardiovascular disease prevention today. Inhaltsverzeichnis PREFACE xv ACKNOWLEDGMENTS xxxi ABBREVIATIONS xxxiii SECTION 1 NORMAL FUNCTIONAL HIGH-DENSITY LIPOPROTEIN 1 1 COMPOSITION 3 1.1 Proteome / 9 Apolipoproteins / 9 Apolipoprotein A-I / 9 ApoA-II / 9 ApoA-IV / 9 ApoA-V / 10 ApoC-I, ApoC-II, ApoC-III, ApoC-IV / 12 ApoD / 12 ApoE / 13 ApoF / 14 ApoH / 14 ApoJ / 14 ApoL-I / 15 ApoM / 15 Other Apolipoproteins / 15 Enzymes / 16 LCAT / 16 PON1 and PON3 / 16 PAF-AH (LpPLA2) / 17 GSPx-3 / 18 Lipid Transfer Proteins / 18 PLTP / 18 CETP / 19 Acute-Phase Response Proteins / 19 Serum Amyloid A / 19 Other Proteins / 20 Complement Components / 21 Proteinase Inhibitors and Related Proteins / 23 Other Protein Components / 25 1.2 Lipidome / 27 Phospholipids / 27 Steroids / 28 Cholesteryl Esters / 28 Triglycerides / 28 Minor Lipids / 28 2 HETEROGENEITY 39 2.1 Heterogeneity in Physicochemical Properties / 42 Heterogeneity in Density / 42 Heterogeneity in Electrophoretic Mobility / 43 Heterogeneity in Size / 45 2.2 Heterogeneity in Chemical Composition / 47 Heterogeneity in Proteins / 47 Heterogeneity in Lipids / 49 2.3 Relationships Between HDL Subfractions Separated by Different Methods / 50 3 STRUCTURE 59 3.1 Lipid-Free ApoA-I / 59 3.2 Discoid HDL /...

List of contents

PREFACE xv
 
ACKNOWLEDGMENTS xxxi
 
ABBREVIATIONS xxxiii
 
SECTION 1 NORMAL FUNCTIONAL HIGH-DENSITY LIPOPROTEIN 1
 
1 COMPOSITION 3
 
1.1 Proteome / 9
 
Apolipoproteins / 9
 
Apolipoprotein A-I / 9
 
ApoA-II / 9
 
ApoA-IV / 9
 
ApoA-V / 10
 
ApoC-I, ApoC-II, ApoC-III, ApoC-IV / 12
 
ApoD / 12
 
ApoE / 13
 
ApoF / 14
 
ApoH / 14
 
ApoJ / 14
 
ApoL-I / 15
 
ApoM / 15
 
Other Apolipoproteins / 15
 
Enzymes / 16
 
LCAT / 16
 
PON1 and PON3 / 16
 
PAF-AH (LpPLA2) / 17
 
GSPx-3 / 18
 
Lipid Transfer Proteins / 18
 
PLTP / 18
 
CETP / 19
 
Acute-Phase Response Proteins / 19
 
Serum Amyloid A / 19
 
Other Proteins / 20
 
Complement Components / 21
 
Proteinase Inhibitors and Related Proteins / 23
 
Other Protein Components / 25
 
1.2 Lipidome / 27
 
Phospholipids / 27
 
Steroids / 28
 
Cholesteryl Esters / 28
 
Triglycerides / 28
 
Minor Lipids / 28
 
2 HETEROGENEITY 39
 
2.1 Heterogeneity in Physicochemical Properties / 42
 
Heterogeneity in Density / 42
 
Heterogeneity in Electrophoretic Mobility / 43
 
Heterogeneity in Size / 45
 
2.2 Heterogeneity in Chemical Composition / 47
 
Heterogeneity in Proteins / 47
 
Heterogeneity in Lipids / 49
 
2.3 Relationships Between HDL Subfractions Separated by Different Methods / 50
 
3 STRUCTURE 59
 
3.1 Lipid-Free ApoA-I / 59
 
3.2 Discoid HDL / 62
 
3.3 Spherical HDL / 66
 
4 METABOLISM 74
 
4.1 Formation and Intravascular Remodeling / 74
 
ABC Transporters / 77
 
ABCA1 / 77
 
ABCG1 / 85
 
Enzymes / 86
 
LCAT / 86
 
Lipases / 88
 
Lipid Transfer Proteins / 90
 
CETP / 90
 
PLTP / 92
 
Receptors / 93
 
SR-BI / 93
 
4.2 Catabolism / 96
 
5 EPIDEMIOLOGY 113
 
5.1 Epidemiology of HDL-C / 113
 
HDL-C and Cardiovascular Risk / 113
 
Relevance Across Multiple Populations and Disease States / 116
 
HDL-C and Other Cardiovascular Risk Factors / 120
 
Prevalence of Low HDL-C / 122
 
HDL-C and Cardiovascular Risk in Patients Receiving Statins / 123
 
HDL-C and Other Major Diseases / 125
 
5.2 Epidemiology of HDL-Associated Proteins and Enzymes / 126
 
ApoA-I / 126
 
Other Apolipoproteins / 129
 
SAA / 130
 
PON1 / 130
 
PAF-AH / 131
 
Other Enzymes / 133
 
Lipid Transfer Proteins / 133
 
5.3 Epidemiology of HDL Particle Subpopulations / 134
 
Separated by Density / 134
 
Separated by Electrophoretic Mobility / 135
 
Separated by Composition / 135
 
Separated by Size / 135
 
6 GENETICS 161
 
6.1 ABC Transporters and Other Receptors / 165
 
ABCA1 / 165
 
SR-BI / 167
 
LDL Receptor / 167
 
6.2 Apolipoproteins / 167
 
ApoA-I / 167
 
ApoA-V / 168
 
ApoC-III / 168
 
ApoE / 168
 
6.3 Enzymes / 169
 
LCAT / 169
 
PON1 / 169
 
LPL / 170
 
Hepatic Lipase / 171
 
Endothelial Lipase / 171
 
6.4 Lipid Transfer Proteins / 172
 
CETP / 172
 
6.5 Other Genes / 174
 
6.6 Gene Interactions / 176
 
7 BIOLOGIC ACTIVITIES 192
 
7.1 Cholesterol Effl

Report

"In summary, the need for this book is immense: It is an encyclopedia where everyone working in or near the field can quickly find the fact or reference they need. It is a textbook one can give to a student on the first day in the lab. It is a novel that can be read when running out of controversies in your own field." ( ChemMedChem , 1 April 2013)

Product details

• Authors: Chapman, M John Chapman, M. John Chapman, Chapman M. John, Kontush, A Kontush, Anato Kontush, Anatol Kontush, Anatol Chapman Kontush, Anatol/ Chapman Kontush, Kontush Anatol, KONTUSH ANATOL CHAPMAN M JOHN
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 20.02.2012
• EAN: 9780470408216
• ISBN: 978-0-470-40821-6
• No. of pages: 648
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, Medizin, KARDIOVASKULÄRE ERKRANKUNGEN, chemistry, Medical Science, Pharmaceutical & Medicinal Chemistry, Pharmazeutische u. Medizinische Chemie, Kardiovaskuläre Erkrankung, Biochemie u. Chemische Biologie, Biochemistry (Chemical Biology), Cardiovascular Disease