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Informationen zum Autor Dr Andrew E. Williams, Imperial College, London, UK. Klappentext Immunology Mucosal and Body Surface DefencesThe vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology.After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemokines, before covering the workings of the mucosal immune system. It continues by examining immunity against the four major groups of pathogens - viruses, bacteria, fungi and parasites, and concludes by looking at disorders of the immune system, mucosal tumour immunology and the process of vaccination.* A fresh, new approach to the subject focusing on mucosal and body surfaces.* Describes the mucosal immune systems of the gastrointestinal, respiratory and urogenital tracts, as well as the skin.* Details the important roles of cytokines and chemokines in an immune response.* Separate chapters devoted to immunity against viruses, bacteria, fungi and parasites.* Includes chapter summaries, boxes with topics of special interest and an extensive glossary.* Clearly written and well- illustrated in full colour throughout.Students across a range of disciplines, including biology, biochemistry, biomedicine, medicine and veterinary sciences, will find this book invaluable, both as an introduction to basic immunology and as a guide to mucosal immune defence mechanisms. Zusammenfassung Immunity: Mucosal Immunology in Health and Disease provides a realistic approach to the teaching of immunology, dealing with immunity at specific sites in the body a novel approach not adopted in current books. This book is the first immunology textbook to focus on the mucosa, the largest immune organ in the body. Inhaltsverzeichnis Preface, xv List of Standard Cells and Symbols, xvii 1 Basic Concepts in Immunology, 1 1.1 The immune system, 1 1.2 Tissues and cells of the immune system, 1 1.3 Activation, regulation and functions of immune responses, 4 1.4 Innate versus adaptive immunity, 5 1.5 Primary and secondary immune responses, 6 1.6 Immune cell development, 7 1.7 Mast cells and basophils, 9 1.8 Eosinophils, 11 1.9 Neutrophils, 11 1.10 Monocytes and macrophages, 11 1.11 Dendritic cells, 12 1.12 Natural killer cells, 12 1.13 CD4+ T helper cells, 13 1.14 CD8+ cytotoxic T cells, 14 1.15 B cells, 15 1.16 ¿¿ T cells, 16 1.17 Natural killer T cells, 16 1.18 Anatomy of the immune system, 16 1.19 Lymph nodes, 16 1.20 Spleen, 19 1.21 Summary, 19 2 The Innate Immune System, 20 2.1 Introduction to the innate immune system, 20 2.2 Innate immune receptors and cells, 20 2.3 TLRs and pattern recognition, 22 2.4 TLR signalling in response to LPS, 23 2.5 Peptidoglycan and Nods, 24 2.6 Nod-like receptors recognize PAMPs and DAMPs, 25 2.7 Damage associated molecular patterns (DAMPs), 26 2.8 Complement proteins perform several innate immune functions, 27 2.9 The classical complement pathway, 28 2.10 The lectin and alternative complement pathways, 29 2.11 Biological properties of complement cleavage products, 29 2.12 Opsonization by complement proteins, 30 2.13 Phagocytosis, 31 2.14 Fc receptors induce phagocytosis, 32 2.15 Neutrophil function and the respiratory burst, 32 2.16 ADCC, 33 2.17 NK cells recognize missing self, 35 2.18 Activating adaptive...
