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In modern ecotoxicology, fish have become the major vertebrate model, and a tremendous body of information has been accumulated.
This volume attempts to summarize our present knowledge in several fields of primary ecotoxicological interest ranging from the use of (ultra)structural modifications of selected cell systems as sources of biomarkers for environmental impact over novel approaches to monitoring the impact of xenobiotics with fish in vitro systems such as primary and permanent fish cell cultures, the importance of early life-stage tests with fish, the bioaccumulation of xenobiotics in fish, the origin of liver neoplastic lesions in small fish species, immunocytochemical approaches to monitoring effects in cytochrome P450-related biotransformation, the impact of heavy metals in soft water systems, the environmental toxicology of organotin compounds, oxidative stress in fish by environmental pollutants to effects by estrogenic substances in aquatic systems.
List of contents
Fish cell lines as a tool in aquatic toxicology, Helmut Segner; primary cell cultures from fish in ecotoxicology, Gilles Monod et al; cytological alterations in fish hepatocytes In Vivo and In Vitro sublethal exposure to xenobiotics - structural biomarkers of environmental contamination, Thomas Braunbeck; architectural pattern, tissue and cellular morphology in livers of fishes - relationships to experimentally-induced neoplastic responses, David E. Hinton, John A. Couch; immunochemical approaches to studies of CYPIA localization and induction of xenobiotics in fish, Anders Goksoyr, Astrid-Mette Husoy; oxidative stress in fish by environmental pollutants, Reinhard Lackner; origin of cadmium and lead in clear softwater lakes of high-altitude and high-latitude, and their bioavailability and toxicity to fish, Gunter Kock, Rudolf Hofer; effects of organotin compounds in fish - from the molecular to the population level, Karl Fent; multiple stressors in the Sacramento watershed, David E. Hinton; effects of oestrogenic substances in the aquatic environment, Peter Matthiessen, John P. Sumpter; testing of chemicals with fish - a critical evaluation of tests with special regard to zebrafish, Roland Nagel, Karla Isberner; bioaccumulation of xenobiotics in fish, Bruno Streit.
