Advances in Immunology

Informationen zum Autor Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School. Klappentext Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Zusammenfassung Presents developments as well as comprehensive reviews in immunology. This title addresses a range of topics that comprise immunology! including molecular and cellular activation mechanisms! phylogeny and molecular evolution! and clinical modalities. Inhaltsverzeichnis Contributors Early Steps of Follicular Lymphoma Pathogenesis 1. Follicular Lymphoma 2. The Classical Model of Follicular Lymphomagenesis 3. Circulating and Resident t(14;18) Cells Detected in Healthy Individuals are not Naive B-Cells 4. The "Allelic Paradox?: A Particular Immuno/Genophenotype of t(14;18)+ Activated B-Cells Which Does Not Match Any of the Physiological Memory Subsets Present in Blood 5. A Fraction of t(14;18) Cells in Healthy Carriers are Developmentally "Blocked? Follicular Lymphoma-Like Cells (FLLC) 6. BCL2, BCL6, Maturation Arrest, and the Role of the IgM Receptor 7. Trafficking, Early Dissemination, and Progression 8. A Protracted Model of Multi-Hit FL Genesis 9. Perspectives Acknowledgments "A Rose is a Rose is a Rose,? but CVID is Not CVID 1. Introduction 2. Definition and Diagnostic Criteria 3. Epidemiology 4. Pathophysiology/Immunopathology 5. Etiology/Genetics 6. CVID Classification Schemes 7. Clinical Presentation and Complications 8. Management 9. Prognosis and Survival 10. Summary Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development Abbreviations 1. Introduction: Cancer as a Genetic Disease 2. Nucleotide-Editing Enzymes as Inducers of Mutations 3. Physiologic Roles of AID in Antibody Production 4. Regulation of AID Expression in B Cells 5. Excessive AID Activity and Genetic Alterations Leading to Tumorigenesis 6. Roles of AID in Inflammation-Associated Human Carcinogenesis 7. Role of AID in the Development of Hematopoietic Malignancy 8. Conclusion Acknowledgments Comparative Genomics and Evolution of Immunoglobulin-Encoding Loci in Tetrapods 1. Introduction 2. Structure and Function of Ant...

List of contents

Contributors
Early Steps of Follicular Lymphoma Pathogenesis
1. Follicular Lymphoma
2. The Classical Model of Follicular Lymphomagenesis
3. Circulating and Resident t(14;18) Cells Detected in Healthy Individuals are not Naive B-Cells
4. The "Allelic Paradox”: A Particular Immuno/Genophenotype of t(14;18)+ Activated B-Cells Which Does Not Match Any of the Physiological Memory Subsets Present in Blood
5. A Fraction of t(14;18) Cells in Healthy Carriers are Developmentally "Blocked” Follicular Lymphoma-Like Cells (FLLC)
6. BCL2, BCL6, Maturation Arrest, and the Role of the IgM Receptor
7. Trafficking, Early Dissemination, and Progression
8. A Protracted Model of Multi-Hit FL Genesis
9. Perspectives
Acknowledgments
"A Rose is a Rose is a Rose,” but CVID is Not CVID
1. Introduction
2. Definition and Diagnostic Criteria
3. Epidemiology
4. Pathophysiology/Immunopathology
5. Etiology/Genetics
6. CVID Classification Schemes
7. Clinical Presentation and Complications
8. Management
9. Prognosis and Survival
10. Summary
Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development
Abbreviations
1. Introduction: Cancer as a Genetic Disease
2. Nucleotide-Editing Enzymes as Inducers of Mutations
3. Physiologic Roles of AID in Antibody Production
4. Regulation of AID Expression in B Cells
5. Excessive AID Activity and Genetic Alterations Leading to Tumorigenesis
6. Roles of AID in Inflammation-Associated Human Carcinogenesis
7. Role of AID in the Development of Hematopoietic Malignancy
8. Conclusion
Acknowledgments
Comparative Genomics and Evolution of Immunoglobulin-Encoding Loci in Tetrapods
1. Introduction
2. Structure and Function of Antibodies
3. Ig-Heavy Chain in Tetrapods
4. Ig-Light Chains in Tetrapods
5. Evolution of Immunoglobulin J-Chain
6. Noncanonical Antibodies in Camelids
7. Concordance and Divergence of the Generation of Antibody Diversity
8. Concluding Remarks
Acknowledgments
Pax5
1. Pax5 and B Cell Commitment
2. Pax5 and the Control of Igh Rearrangements
3. Pax5 and Late B Cell Development
4. Role of Pax5 in B Cell Malignancies
5. Perspective
Acknowledgments

Report

"The series which all immunologists need." --The Pharmaceutical Journal
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Product details

• Authors: Frederick W. (EDT) Alt
• Assisted by: Frederick W Alt (Editor), Frederick W. Alt (Editor), Frederick W. (Howard Hughes Medical Institute Research Laboratories Alt (Editor), Frederick W. (Investigator and Director Alt (Editor), Frederick W. (Investigator and Director of the Program in Cellular and Molecular Medicine Alt (Editor), Alt Frederick W. (Editor)
• Publisher: Academic Press London
• Languages: English
• Product format: Hardback
• Released: 01.10.2011
• EAN: 9780123859914
• ISBN: 978-0-12-385991-4
• No. of pages: 236
• Series: Academic Press; Advances in Immunology; Academic Press; Advances in Immunology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Immunology, MEDICAL / Immunology