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Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds. Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices. With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair ...
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Introduction
Part I: Introduction to chronic wounds
Chapter 1: Dysfunctional wound healing in chronic wounds
Abstract:
1.1 Normal skin wound healing
1.2 Ageing skin and the onset of chronic, dysfunctional wound healing
1.3 Dysfunctional healing of chronic skin wounds
1.4 Conclusions
1.5 Acknowledgements
Chapter 2: The role of micro-organisms and biofilms in dysfunctional wound healing
Abstract:
2.1 Introduction
2.2 Microbiology and biofilms: not mutually exclusive
2.3 Biofilms and the interactive cooperative community
2.4 Biofilms in chronic wounds
2.5 Biofilms as therapeutic or restorative microbiology/modeling
2.6 Conclusion
Chapter 3: Scarring and scarless wound healing
Abstract:
3.1 Introduction
3.2 Wound healing process
3.3 Fibroproliferative scarring
3.4 Scarless fetal wound healing
3.5 Adult versus fetal wound healing
3.6 Treatment options for scars
3.7 Future trends
3.8 Conclusions
Chapter 4: The discovery and development of new therapeutic treatments for the improvement of scarring
Abstract:
4.1 Introduction
4.2 Scar-free and scar-forming healing
4.3 In vitro and in vivo models to investigate the mechanisms of scarring and evaluate potential treatments
4.4 Translation from pre-clinical studies to clinical efficacy
4.5 Understanding the mechanisms of action of prophylactic scar improvement therapies
4.6 Conclusions
Chapter 5: Monitoring chronic wounds and determining treatment
Abstract:
5.1 Introduction
5.2 Wound size measurements
5.3 Wound colour measurements
5.4 Background material
Part II: Biomaterial therapies for chronic wounds
Chapter 6: Functional requirements of wound repair biomaterials
Abstract:
6.1 Introduction
6.2 Wound pain and dressing materials
6.3 Exudate management
6.4 Prevention and control of infection
6.5 Odour management
6.6 Future trends
6.7 Sources of further information and advice
Chapter 7: Tissue-biomaterial interactions
Abstract:
7.1 Introduction: definitions
7.2 Overview of tissue-biomaterial interactions
7.3 Interactions at the biomaterial surface
7.4 Tissue response to biomaterial
7.5 Conclusion
Chapter 8: Polymeric materials for chronic wound and burn dressings
Abstract:
8.1 Introduction
8.2 Advanced moisture-retentive wound dressings
8.3 Polymeric materials in moist wound healing dressings
8.4 Infection control by polymeric wound dressings
8.5 Conclusion
8.6 Future trends
8.7 Acknowledgements
Chapter 9: Dry wound healing concept using spray-on dressings for chronic wounds
Abstract:
9.1 Introduction
9.2 The key properties of an ideal wound dressing
9.3 Using protein-based spray-on dressings in practice
9.4 Case studies
9.5 Conclusions
Chapter 10: Assessing the effectiveness of antimicrobial wound dressings in vitro
Abstract:
10.1 Introduction
10.2 Log reduction testing
10.3 Zone of inhibition (ZOI)
10.4 Bacterial barrier testing
10.5 Other considerations
10.6 Sources of further information and advice
Chapter 11: Adhesives and interfacial phenomena in wound healing
Abstract:
11.1 Principles of adhesion, adhesivity and interfacial behaviour
11.2 Bioadhesion: principles of adhesion applied to wound healing
11.3 Adhesives in wound healing: materials overview
11.4 Surgical adhesives and tissue sealants: structure and properties
11.5 Conclusions
Chapter 12: Wound healing studies and interfacial phenomena: use and relevance of the corneal model
Report
"... comprises a nice overview of various kinds of therapies and a sufficiently extensive discussion of important (future) materials and treatments. This without neglecting the basics." --Biomat.net, April 2013
"The book comprises a nice overview of various kinds of therapies and a sufficiently extensive discussion of important (future) materials and treatments." --Birgit Stubbe, Biomaterials Network
