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Informationen zum Autor Jian Zhou is a Professor of Chemistry in the Shanghai Key Laboratory of Green Chemistry and Chemical Processes at East China Normal University. He has broad experience in asymmetric catalysis and has published over 30 papers in leading scientific journals after his independent research. Dr. Zhou's research focuses on the development of new chiral catalysts and catalytic asymmetric reactions for the efficient construction of fully substituted stereogenic carbon centres, as well as economical synthesis and novel tandem reactions. Klappentext Methods and applications of multicatalyst systems in asymmetric catalysis Asymmetric catalysis plays an important role in the synthesis of chiral compounds, due to their high efficiency and selectivity that traditional methods cannot reach. This book provides details about the mechanism and advantages of multicatalysis systems in asymmetric catalysis. Examples in this book introduce the difference between multifunctional catalysis and multiple catalyst systems and cover the important and exciting results of multiple catalyst promoted asymmetric reactions and novel tandem reactions. Using examples and step-by-step methods, the chapters cover a variety of pertinent topics including: - Additive-enabled asymmetric metric catalysis - Asymmetric multifunctional catalysis - Asymmetric cooperative catalysis - Asymmetric double activation catalysis, assisted catalysis, photochemical and electrochemical methods - Multicatalyst system realized asymmetric tandem reaction - Waste-mediated Reactions - Multicatalyst system mediated asymmetric reactions in total synthesis In addition, this book focuses on applications and greener ways to make useful substances for pharmaceuticals, agrochemicals, materials, and flavour and fragrance industries. Zusammenfassung This book introduces multi-catalyst systems by describing their mechanism and advantages in asymmetric catalysis. Inhaltsverzeichnis Preface xi Contributors xiv 1 Toward Ideal Asymmetric Catalysis 1 Jian Zhou and Jin-Sheng Yu 1.1 Introduction 1 1.2 Challenges to Realize Ideal Asymmetric Catalysis 7 1.3 Solutions 13 1.4 Borrow Ideas from Nature 22 1.5 Conclusion 32 References 32 2 Multicatalyst System 37 Zhong-Yan Cao Feng Zhu and Jian Zhou 2.1 Introduction 37 2.2 Models of Substrate Activation 42 2.2.1 The Activation of Electrophiles 43 2.2.2 The Activation of Nucleophiles 54 2.2.3 SOMO Catalysis 64 2.3 Early Examples of the Application of Multicatalyst System in Asymmetric Catalysis 66 2.4 A General Introduction of Multicatalyst-Promoted Asymmetric Reactions 85 2.5 Classification of Multicatalyst-Promoted Asymmetric Reactions 95 2.6 Challenges and Possible Solutions 97 2.7 Multicatalyst System Versus Multifunctional Catalyst 103 2.8 Multicatalyst System Versus Additives-Enhanced Catalysis 105 2.9 Additive-Enhanced Catalysis 107 2.9.1 Nitrogen-containing Organobase 109 2.9.2 Inorganic Bases 111 2.9.3 H2O 114 2.9.4 Molecular Sieves and Dehydrators 120 2.9.5 N-oxide P-oxide and As-oxide 125 2.9.6 Alcohols and Phenols 129 2.9.7 Ammonium Halides and Metal Halides 133 2.9.8 Amides 137 2.9.9 Brønsted Acids and Lewis Acids 140 2.9.10 Two or More Additives Together 144 2.10 Conclusion 147 References 148 3 Asymmetric Multifunctional Catalysis 159 Jin-Sheng Yu and Jian Zhou 3.1 Introduction 159 3.2 Asymmetric Multifunctional Organocatalysis 164 3.2.1 H-Bond Donor-Tertiary Amine Catalysis 165 3.2.2 H-Bond Donor-Enamine Catalysis 193 3.2.3 H-Bond Donor-Phase Transfer Catalysis 203 3.2.4 H-Bond Donor-Tertiary Ph...
