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On May 24-27,1992 the European Society ofOsteoarthrology (ESOA) held its 19th sympo sium in Noordwijkerhout, The Netherlands. The symposium was entitled "Joint destruction in arthritis and osteoarthritis" and sought to combine both clinical and experimental studies in this field. The present volume contains the proceedings of this meeting. The ESOA has organized most of its symposia in the eastern part of Europe, thanks to major input from Stanislav Havelka, who in recent years has been supported by Heikki Helminen. In appreciation of his efforts Stan Havelka was granted Honorary Presidentship of the ESOA at the meeting. In the era of European unification it seemed desirable to create a strong Uni fied European Society, which would organize major meetings in both parts of Europe. Cartilage and bone research is expanding rapidly and the number of meetings in this field is continually growing. In line with these developments discussions took place with the recent Iy founded "Eular Workshop on Bone and Cartilage Research" and the "Osteoarthritis Re search Society (OARS)".
List of contents
Cartilage destruction in arthritis and osteoarthritis.- Osteoarthritis in the human knee: A dynamic process of cartilage matrix degradation, synthesis and reorganization.- Experimental arthritis models in the study of the mechanisms of articular cartilage loss in rheumatoid arthritis.- Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model.- Mechanisms of cartilage destruction in joint inflammation.- Immunopathology.- Synovial fluid analyses detect and differentiate proteoglycan metabolism in canine experimental models of osteoarthritis and disuse atrophy.- Humoral and cell-mediated sensitivity to cartilage constituents in mice with antigen-induced arthritis.- In vitro and in vivo effects of proteoglycan fractions in adjuvant treated rats.- Are antibodies reactive with chondrocyte proteins enriched in synovial fluids of patients with rheumatoid arthritis?.- Joint loading and cartilage metabolism.- The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy.- Effects of long-term running exercise on canine femoral head articular cartilage.- Human and bovine articular cartilage loading measured with a new resistive sensor: Effects of protease degradation and osteoarthritis.- Cytokines and growth factors.- Possible role of IL-1 in arthritis: Effects of prostaglandins in the regulation of IL-1 synthesis and actions.- Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways.- Does TGF-ß protect articular cartilage in vivo?.- Human rheumatoid synovial cells (HRSC) in culture express TGF-ß receptors and are growth stimulated by the factor.- Variable TGF-ß receptor expression regulates TGF-ß responsesof articular chondrocytes.- Proteases and their inhibitors.- Proteolytic degradation in human articular cartilage: Its relationship to Stromelysin.- The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators.- The role of alpha-l-protease inhibitor (A1PI) in the inhibition of protease activity in human knee osteoarthritis.- Recombinant human protease nexin-1 prevents articular cartilage- degradation in the rabbit.- Therapeutic modulation of destruction.- In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes.- Animal models of early osteoarthritis: Their use for the evaluation of potential chondroprotective agents.- The in vivo effects of Naproxen on canine experimental osteoarthritic articular cartilage: Composition, metalloproteinase activities and metabolism.- Interleukin-1 and Naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC).- Effect of Rumalon (glycosaminoglycan-peptide) on the articular tissue.- Doxycycline protects serum alpha-l-antitrypsin from human neutrophil collagenase.- In vitro construction of cells-containing implants for articular cartilage regeneration.- Cellular aspects on treatment of cartilage injuries.- Human meniscus transplantation.- Methodology.- In situ hybridisation for Decorin mRNA in rabbit synovium during antigen-induced arthritis.- Osteoarthritis in rhesus macaques: Assessment of cartilage matrix quality by quantitative magnetic resonance imaging.- A magnetic resonance imaging study of joint degeneration in the guinea pig knee.- Development of immortalized human articular cartilage cell lines.
