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Zusatztext `The book will act as a source of information and ideas for researchers! and as an accessible introduction to the subject for students and clincians.'Anticancer Research Zusammenfassung Recent advances in the study of insulin-like growth factors have led to insight into their role in embryogenesis! cancer and normal growth. This book reviews what is known of the structure and function of the IGFs! with topics ranging from the organization of IGF genes to clinical implications. Inhaltsverzeichnis P.N. Schofield: Introduction; W.H. Daughaday: The historical evolution of concepts of the role of insulin-like growth factors; J.L. Van den Brande: Structure of the human insulin-like growth factors: relationship to function; A. Ward & C.J. Ellis: The insulin-like growth factor genes; C. Moxham & S. Jacobs: Insulin-like growth factor receptors; R.H. McCusker & D.R. Clemmons: The insulin-like growth factor binding proteins: structure and biologicalfunctions; P. Bang & K. Hall: Insulin-like growth factors as endocrine and paracrine hormones; V.K.M. Han & D.J. Hill: The involvement of insulin-like growth factors in embryonic and fetal development; E. Jennische! J. Isagaard & O.G.P. Isaksson: Local expression of insulin-like growth factors; P.N. Schofield & W.Engstrom: Insulin-like growth factors in human cancer; V.R. Sara: The role of insulin-like growth factors in the nervous system; Index.
