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Zusammenfassung This volume records the review meeting celebrating the 65th birthday of Dennis Sciama. The topics covered include fundamental questions in general relativity and cosmology! black holes! active galactic nuclei! galactic structure! dark matter! and large scale structure. Inhaltsverzeichnis Introduction; 1. Exact and inexact solutions of the Einstein field equations G. F. R. Ellis; 2. Inertial forces in general relativity M. A. Abramovicz; 3. Relativistic radiation hydrodynamics A. M. Anile and V. Romano; 4. Relativistic gravitational collapse J. Miller; 5. The cosmic censorship hypothesis C. J. S. Clarke; 6. The Kerr metric: a gateway to the roots of gravity? F. de Felice; 7. Galactic astronomy since 1950 J. J. Binney; 8. Galaxy distribution functions W. C. Saslow; 9. Nonlinear galaxy clustering B. J. T. Jones; 10. Quasars: progress and prospects M. J. Rees; 11. Decaying neutrinos in astronomy and cosmology D. W. Sciama; 12. Cosmological principles J. D. Barrow; 13. Anisotropic and inhomogeneous cosmologies M. A. H. MacCallum; 14. Mach's principle and isotropic singularities P. K. Tod; 15. Implications of superconductivity in cosmic string theory B. Carter; 16. The formation and evaporation of primordial black holes B. J. Carr; 17. Evaporation of two dimensional black holes S. W. Hawking; 18. Topology and topology change in general relativity G. W. Gibbons; 19. Decoherence of the cluttered quantum vacuum D. J. Raine; 20. Quantum nonlocality and complex reality R. Penrose; 21. The different levels of connections between science and objective reality N. Dallaporta.