Read more
Informationen zum Autor Wolf-Karsten Hofmann, MD, PhD is Professor of Medicine in the Department of Hematology, Oncology and Transfusion Medicine, Charite – University Hospital, Berlin. For four successive years he received the Young Investigator Award of the American Society of Hematology, and in addition to his research publications has written many book chapters in haematology and oncology. Klappentext Reviews clinical applications of this promising diagnostic and prognostic technology in cancer and other diseases. Zusammenfassung Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously. This survey spans recent applications of microarrays in clinical medicine! covering malignant disease including acute leukaemias! lymphoid malignancies and breast cancer! together with diabetes and heart disease. Inhaltsverzeichnis Preface Eckhard Thiel; 1. Introduction Wolf-Karsten Hofmann; 2. Technique of microarrays: microarray platforms Sven de Vos; 3. Quantitative quality control of microarray experiments: toward accurate gene expression measurements Xujing Wang and Martin J. Hessner; 4. Statistical analysis of gene expression data David A. Elashoff; 5. Genomic stratification in patients with heart failure Tara A. Bullard, Frédérick Aguilar, Jennifer L. Hall and Burns C. Blaxall; 6. Gene expression profiling for the diagnosis of acute leukemias Torsten Haferlach, Alexander Kohlmann, Susanne Schnittger, Claudia Schoch and Wolfgang Kern; 7. Gene expression profiling can distinguish tumour subclasses of breast carcinomas Ingrid A. Hedenfalk; 8. Gene expression profiling in lymphoid malignancies Christof Burek, Elena Hartmann, Zhengrong Mao, German Ott and Andreas Rosenwald; 9. MRNA profiling of pancreatic beta cells: investigating mechanisms of diabetes Leentje Van Lommel, Yves Moreau, Daniel Pipeleers, Jean-Christophe Jonas and Frans Schuit; 10. Prediction of response and resistance to treatment by gene expression profiling Philipp Kiewe and Wolf-Karsten Hofmann....
