Dynamic Studies Through Control of Relaxation in NMR Spectroscopy

Nicola Salvi's thesis offers a remarkably cogent view of highly sophisticated NMR methods. Salvi developed these methods in order to characterize the amplitudes and frequency ranges of local motions in biomolecules such as proteins. These local motions play an essential role since they can explain many of the remarkable properties of proteins and enable them to carry out all sorts of vital functions, from enzymatic catalysis to intermolecular recognition and signalling in cells. Salvi's work has led to numerous publications in high-impact journals.

List of contents

Introduction.- Theoretical principles.- Analytical models for relaxation dispersion experiments.- Experimental methods.- Experimental results.- Conclusions.

About the author

Dr. Salvi completed his PhD thesis at the Swiss Federal Institute of Technology in Lausanne and he is currently a postdoctoral researcher at Harvard Medical School. He is interested in the development of Nuclear Magnetic Resonance (NMR) methods for the study of protein function and for drug discovery.

Summary

Nicola Salvi's thesis offers a remarkably cogent view of highly sophisticated NMR methods. Salvi developed these methods in order to characterize the amplitudes and frequency ranges of local motions in biomolecules such as proteins. These local motions play an essential role since they can explain many of the remarkable properties of proteins and enable them to carry out all sorts of vital functions, from enzymatic catalysis to intermolecular recognition and signalling in cells. Salvi's work has led to numerous publications in high-impact journals.

Product details

• Authors: Nicola Salvi
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2014
• EAN: 9783319061696
• ISBN: 978-3-31-906169-6
• No. of pages: 110
• Dimensions: 163 mm x 243 mm x 13 mm
• Weight: 315 g
• Illustrations: XIX, 110 p. 41 illus., 10 illus. in color.
• Series: Springer Theses; Springer Theses
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Physical chemistry; B, Medical research, molecular biology, Chemistry and Materials Science, spectroscopy, Measurement, Spectroscopy/Spectrometry, Scientific standards, measurement etc, Measurement Science and Instrumentation, Physical measurements, Biomedical Research, Biomedical Engineering and Bioengineering, Biomedical engineering, Molecular Medicine