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Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner.
"..a spectacular and seemingly comprehensive review of rheumatology." Reviewed by Dr. Harry Brown, on behalf of glycosmedia.com, December 2014
List of contents
Section 1: The Scientific Basis of Rheumatic Disease
1. Epidemiologic concepts and the classification of rheumatic and musculoskeletal conditions
2. Principles of clinical outcome assessment
3. Principles of health economics and application to rheumatic disorders
4. The synovium
5. The articular cartilage
6. Bone structure and function
7. Tendons and ligaments
8. Connective tissue responses to mechanical stresses
9. Biomechanics of peripheral joints
10. Biomechanics of the spine
11. Principles of genetic epidemiology
12. Principles and techniques in molecular biology
13. Cytokines
14. Signal transduction in immune cells
15. The principles of adaptive immunity
16. Principles of innate immunity
17. Systems biology
18. Epigenetics in Rheumatology
19. The microbiome in rheumatic diseases
20. Tissue destruction and repair
21. Principles of tissue engineering and cell- and gene-based therapy
22. Osteoimmunology
23. Inflammation and its mediators
24. Scientific basis of pain
25. Effects of the neuroendocrine system on development and function of the immune system
26. Interpreting the medical literature for the rheumatologist: study design and levels of evidence
27. Ethics in clinical trials
Section 2: Clinical Basis of Rheumatic Disease
28. History and physical examination
29. Pattern recognition in arthritis
30. Role of laboratory tests in rheumatic disorders
31. Synovial fluid analysis
32. Minimally invasive procedures
33. Skin in rheumatic disease
34. The eye in rheumatic disease
35. The heart in rheumatic disease
36. The lung in rheumatic disease
37. Gastrointestinal tract and rheumatic disease
38. The kidney and rheumatic disease
39. The nervous system in rheumatic disease
Section 3: Evaluation: Imaging Techniques
40. Conventional radiography and computed tomography
41. Functional magnetic resonance imaging
42. Musculoskeletal ultrasound
43. Bone scintigraphy and positron emission tomography
44. Dual x-ray absorptiometry and measurement of bone
45. Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials
Section 4: Principles of Management
46. Arthritis patient education, health promotion, and team approaches to management
47. Principles of rehabilitation: physical and occupational therapy
48a. Complementary and alternative medicine
48b. Placebos, Caring and Healing in Rheumatology
49. Drug Development
50. Non-pharmacologic pain management
51. Pharmacogenomics in rheumatology
52. Principles of opioid treatment of chronic musculoskeletal pain
53. Non-steroidal anti-inflammatory drugs
54. Systemic glucocorticoids in rheumatology
55. Nonimmunosuppresive disease-modifying antirheumatic drugs
56. Methotrexate
57. Leflunomide
58. Immunosuppressives: cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil
59. T-cell costimulation and other directed therapies
60. B-Cell depletion
61. Cytokine neutralizers: interleukin-1 inhibitors
62. Interleukin-6 Inhibition
63. Tumor necrosis factor blocking therapies
64. Kinase inhibition: a new therapeutic principle in rheumatology
65. Emerging therapeutic targets: GM-CSF, IL-17and IL-23
66. Biosimilars in Rheumatology
67. Infections and biologic therapy in rheumatoid arthritis: an update on risk and prevention
68. Drugs and pregnancy
69. Aspiration and injection of joints and periarticular tissues and intralesional therapy
70. Perioperative care of patients with rheumatic disease
Section 5: Regional and Widespread Pain
71. Neck pain
72. Lumbar spine disorders
73. The shoulder
74. The elbow
75. The wrist and hand
76. The hip
77. The knee
78. The ankle and foot
79. The temporomandibular joint
80. Fibromyalgia and related syndrome
81. Entrapment neuropathies and com
