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Informationen zum Autor Philip Fuchs began his career at Purdue in 1973. Since that time, he has graduated an extended family of 55 Ph.D.s. His awards and honors include an Eli Lilly young faculty fellowship (1975), an Alfred P. Sloan fellowship (1977), a Pioneer in Laboratory Robotics award (1986), a Martin teaching award (1991), and being voted by the students as one of Top 10 Teachers in School of Science at Purdue (1991, 1993, 1995, 1996). Fuchs has consulted for Pfizer, and Eli Lilly, served on the editorial board of The Journal of Organic Chemistry, and is currently an executive editor for the Electronic Encyclopedia of Organic Reagents (e-EROS), an online dynamic encyclopedia published by John Wiley & Sons. Klappentext Over the last three decades the importance of organosilicon chemistry has greatly increased because it has opened a number of new synthetic strategies. Silicon reagents are usually low-cost, versatile and allow a wide range of reactions. This is the first Handbook to compile essential Silicon containing reagents and makes use of the leading reagent database e-EROS. Another hot volume in the series Handbooks of Reagents for Organic Synthesis, this is a must-have resource for all synthetic chemists working in drug development and medicinal chemistry.For the selection the Editor focussed on three key synthetic approaches with the greatest impact:1. Use of silicon as a 'temporary tether' by unifying a reactive pair of functional groups and taking advantage of their template-biased intramolecular cyclization.2. The specific use of the silane functionality as a hetero t-butyl group, often colloquially referred to as the use of silicon as a 'fat proton'.3. The use of the Brook rearrangement as an 'anion relay stratagem'.A new feature in this Handbook is the reagent finder, an alphabetically organized lookup table arranged by organic functionality and specific structure of the silicon atom to which it is bound. Zusammenfassung Over the last three decades the importance of organosilicon chemistry has greatly increased because it has opened a number of new synthetic strategies. Silicon reagents are usually low-cost, versatile and allow a wide range of reactions. Inhaltsverzeichnis Preface xiii Introduction xv Reagent Finder Table xxiii Short Note on InChIs and InChIKeys xxxi 3-Acetoxy-2-trimethylsilylmethyl-1-propene 1 Allyl(2-chloroethyl)dimethylsilane 9 Allyl Trichlorosilane 10 Allyltrimethylsilane 14 Allyltrimethylsilylzinc Chloride 24 Ammonium Hexafluorosilicate 25 Azidotrimethylsilane 26 Benzene, [[Difluoro(trimethylsilyl)methyl]seleno] 33 Benzene, [[Difluoro(trimethylsilyl)methyl]thio]- 36 Benzene, [[(1 E )-2-(Trimethylsilyl)ethenyl]seleno] 39 Benzene, [[(1 E )-2-trimethylsilyl)ethenyl]sulfonyl]- 42 2,1-Benzoxasilole, 1,3-Dihydro-1,1-dimethyl- 43 N -Benzyl- N -(methoxymethyl)- N trimethylsilylmethylamine 44 1,2-Bis( t -butyldimethylsilyl)hydrazine 46 1,2-Bis(chlorodimethylsilyl)ethane 48 1,4-Bis(dimethylamino)-1,1,4,4-tetramethyldisilethylene 50 Bis(1-methoxy-2-methyl-1-propenyloxy)dimethylsilane 51 Bis(methylthio)(trimethylsilyl)methane 52 [Bis(2-pyridyldimethylsilyl)methyl]lithium 54 1,3-Bis(triisopropylsilyl)propyne 56 N,O -Bis(trimethylsilyl)acetamide 58 (1 E ,3 E )-1,4-Bis(trimethylsilyl)-1,3-butadiene 73 Bis( ß -trimethylsilylethanesulfonyl)imide 74 N,O -Bis(trimethylsilyl)hydroxylamine 75 Bis[(trimethylsilyl)methyl]zinc 76 Bis(trimethylsilyl) Peroxide 79 Bis(trimethylsilyl) Selenide 82 Bis(trimethylsilyl) Sulfide 83 Bromomagnesium Hexamethyldisilazide 85 (Bromomethyl)chlorodimethylsilane 85 Bromotrimethylsilane 92 ( E )...
